Keywords: Brugada syndrome; Channelopathy; Genetic testing; Nav1.5; SCN5A;
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Keywords: CP; 3-carboxy-proxyl; CPH; 1-Hydroxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine; Nav1.5; Voltage gated sodium channel isoform; NCAM; Neural cell adhesion molecule; NEM; N-ethylmaleimide; NMJ; Neuromuscular junction; NOX2; NAD(P)H oxidase 2; Prdx; Peroxiredo
Keywords: AP; action potential; APD; action potential duration; APD80; action potential duration at 80% repolarization; ApoE; apolipoprotein E; ApoE-/-; apolipoprotein E deficient; CD68; cluster of differentiation 68 macrophage marker; CV; conduction velocity;
Keywords: Perinexus; Gap junction; Connexin; Sodium channel; Nav1.5; Ephaptic; Intercalated disk; Conduction;
Keywords: AP; action potential; ArgMe; arginine methylation; bmp; beats per minute; CFP or YFP; cyan or yellow fluorescent protein; co-IP; co-immunoprecipitation; FRET; Förster resonance energy transfer; HEK; human embryonic kidney; IP; immunoprecipitation; LI-I
Keywords: AKAP; A-kinase anchor protein; Ang II; angiotensin II; AP; action potential; APD; action potential duration; BH4; tetrahydrobiopterin; cAMP; cyclic adenosine monophosphate; CaM; calmodulin; CaMKII; Ca/calmodulin-dependent protein kinase II; CaMKIIδC; cyt
1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition
Keywords: 3-(Sulfonyl)-1,2,4-triazole; Triazolesulfone; Bioisostere; Acylsulfonamide; pKa; Sodium channel; NaV1.7; NaV1.5; Pain;
Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6)
Keywords: Ion channel; Fsp3; Bicyclic molecule; hERG; NaV1.5;
Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K+ channel
Keywords: Loperamide; N-Desmethyl loperamide; hERG; KvLQT1; mink; Nav1.5; QT prolongation; QRS prolongation; Cryo-EM docking; ZMOPTLXEYOVARP-UHFFFAOYSA-N; RDOIQAHITMMDAJ-UHFFFAOYSA-N;
Multifocal atrial and ventricular premature contractions with an increased risk of dilated cardiomyopathy caused by a Nav1.5 gain-of-function mutation (G213D)
Keywords: AF; atrial fibrillation; DCM; dilated cardiomyopathy; ECG; electrocardiogram; EPS; electrophysiological study; LA; left atrium; LV; left ventricle; LVEF; left ventricular ejection fraction; MEPPC; multifocal ectopic Purkinje-related premature contractions
Microtubular remodeling and decreased expression of Nav1.5 with enhanced EHD4 in cells from the infarcted heart
Keywords: Nav1.5; EHD4; Microtubules; Post infarction remodeling;
Fusion of Anthopleurin-B to AAV2 increases specificity of cardiac gene transfer
Keywords: AAV; Nav1.5; Anthopleurin-B; Cardiomyocyte; Retargeting; Specificity; Attachment;
O-GlcNAcylation of cardiac Nav1.5 contributes to the development of arrhythmias in diabetic hearts
Keywords: Diabetic mellitus; Arrhythmias; Nav1.5; O-GlcNAc;
Cardiac sodium channel antagonism - Translation of preclinical in vitro assays to clinical QRS prolongation
Keywords: Sodium channel; Nav1.5; QRS interval; In vitro; Clinical; Translation;
Dose-related ethanol intake, Cx43 and Nav1.5 remodeling: Exploring insights of altered ventricular conduction and QRS fragmentation in excessive alcohol users
Keywords: Alcohol consumption; Gap junction; Cx43; Nav1.5; Conduction disturbances;
Voltage gated ion channels blockade is the underlying mechanism of BIMU8 induced cardiotoxicity
Keywords: BIMU8; Cardiac ion channel blockade; hERG; NaV1.5; CaV1.2;
Gain-of-function mutation in SCN5A causes ventricular arrhythmias and early onset atrial fibrillation
Keywords: SCN5A; the gene encoding the α-subunit of the cardiac sodium channel; NaV1.5; cardiac sodium channel; AF; atrial fibrillation; AP; action potential; ECG; electrocardiogram; HEK; human embryonic kidney cell; INa; voltage gated sodium current; MRI; magneti
Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors
Keywords: Sodium channel; NaV1.7; NaV1.5; State-dependent; Pain;
Transcriptional regulation of the sodium channel gene (SCN5A) by GATA4 in human heart
Keywords: ChIP; chromatin immunoprecipitation; cRNA; complementary RNA; ddPCR; droplet digital PCR; GATA-BS; GATA binding sites; HEK; human embryonic kidney; Re-ChIP; sequential ChIP; NaV1.5; sodium channel, voltage-gated, type V alpha subunit; TSS; transcription s
(Re-)programming of subtype specific cardiomyocytes
Keywords: ADSC; adipose tissue-derived mesenchymal stem cell; Alcam; activated leukocyte cell adhesion molecule; AMI; acute myocardial infarction; ANF; natriuretic factor; AP; action potential; ASC; adult stem cell; AV; atrioventricular; AVB; atrioventricular bundl
Disturbed Desmoglein-2 in the intercalated disc of pediatric patients with dilated cardiomyopathy
Keywords: DCM; dilated cardiomyopathy; ID; intercalated disc; LV; left ventricular; HF; heart failure; β-MYH; β-myosin heavy chain; N-cad; N-cadherin; DSC-2; Desmocollin-2; DSG-2; Desmoglein-2; DSP-1; Desmoplakin-1; PKP-2; Plakophilin-2; Cx43; Connexin-43; Nav1.5
Trifluoperazine blocks the human cardiac sodium channel, Nav1.5, independent of calmodulin
Keywords: Trifluoperazine; Calmodulin inhibitor; Voltage-gated sodium channel; Nav1.5; Calmodulin inhibitory peptide;
Local-anesthetic like inhibition of the cardiac sodium channel Nav1.5 α-subunit by 5-HT3 receptor antagonists
Keywords: 5-HT3 receptor antagonist; Tropisetron; Granisetron; Ondansetron; Nav1.5; Local anesthetic
A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias
Keywords: NaV1.5; sodium channels; VCF; voltage clamp fluorometry; F-V; voltage sensor movement; VSD; voltage sensing domain; ECG; electrocardiogram; CPR; cardiopulmonary resuscitation; AED; automated external defibrillators; HEK; human embryonic kidney; EGFP; enha
Molecular basis of the inhibition of the fast inactivation of voltage-gated sodium channel Nav1.5 by tarantula toxin Jingzhaotoxin-II
Keywords: Jingzhaotoxin-II; Nav1.5; Action mechanism;
The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology
Keywords: Cardiac sodium channel; Channelopathies; Nav1.5; SCN5A; Sodium channel kinetics; Nav1.5 biology;
The cardiac sodium channel gene SCN5A and its gene product NaV1.5: Role in physiology and pathophysiology
Keywords: AF; atrial fibrillation; BrS; Brugada syndrome; DCM; dilated cardiomyopathy; ECG; electrocardiogram; Foxo1; Forkhead Box O1; GWAS; Genome Wide Association Study; INa; sodium current; INa,L; late component of the sodium current; Kb; kilobases; LQTS; Long Q
Discovery of pyrrolo-benzo-1,4-diazines as potent Nav1.7 sodium channel blockers
Keywords: Nav1.7; Nav1.5; Pain; Sodium channel blockers; Pyrrolo-benzo-1,4-diazine;
Bioavailable pyrrolo-benzo-1,4-diazines as Nav1.7 sodium channel blockers for the treatment of pain
Keywords: Nav1.7; Nav1.5; Sodium channel; Pain;
Pharmacokinetic-pharmacodynamic modeling of QRS-prolongation by flecainide: Heart rate-dependent effects during sinus rhythm in conscious telemetered dogs
Keywords: Flecainide acetate (PubChem CID: 41022); Nav1.5; QRS; Flecainide; Modeling; Pharmacokinetics; Electrocardiogram; Beagle dog;
Cardiac Sodium Channel Nav1.5 and Drug-Induced Long QT Syndrome
Keywords: Sodium channel; Nav1.5; Long QT syndrome; Drugs; Arrhythmia; hERG;
Brugada Syndrome and Nav1.5
Keywords: Brugada syndrome; Sodium channel; SCN5A gene; Nav1.5;
The tarantula toxin jingzhaotoxin-XI (κ-theraphotoxin-Cj1a) regulates the activation and inactivation of the voltage-gated sodium channel Nav1.5
Keywords: Jingzhaotoxin-XI; Nav1.5; Activation; Inactivation; Gating mechanism;
Dilated Cardiomyopathy and Nav1.5
Keywords: Non-ischemic DCM; SCN5A; Nav1.5; Progressive conduction defect; Cardiac remodeling; Cardiac resynchronization therapy; CRT; Heart transplantation;
A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation
Keywords: AF; atrial fibrillation; AP; action potential; BrS; Brugada syndrome; GFP; green fluorescent protein; HEK293; human embryonic kidney 293; HP; holding potential; INa; inward sodium current; LQTS; long QT syndrome; SNP; single nucleotide polymorphism; SSS;
Conduction Disorders and Nav1.5
Keywords: Atrioventricular block; Cardiac conduction disease; Lev/Lenègre disease; SCN5A; Nav1.5; Channelopathy; Inherited arrhythmia disorder;
NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII
Keywords: NOX2; NADPH oxidase 2; gp91phox; catalytic subunit of NOX2; Ang II; Angiotensin II; ROS; Reactive oxygen species; H89; N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide; SERCA; SR Ca ATPAse; SR; sarcoplasmic reticulum; AIP; autoca
Deletion of FoxO1 leads to shortening of QRS by increasing Na+ channel activity through enhanced expression of both cardiac NaV1.5 and β3 subunit
Keywords: CaMKII; Ca2Â +/calmodulin-dependent protein kinase II; LQTs; Long QT syndromes; LVPWs; Systolic left ventricular posterior wall thickness; LVPWd; Diastolic left ventricular posterior wall thickness; LVIDs; Systolic left ventricular internal diameter; LVID
Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy
Keywords: AC, arrhythmogenic cardiomyopathy; Cx43, connexin43; ID, intercalated disk; N-Cad, N-cadherin; PKG, plakoglobin; PKP2, plakophilin-2; RVSB, Right ventricular septal biopsy; TFC, Task Force CriteriaAC; Arrhythmogenic cardiomyopathy; Connexin 43; NaV1.5; De
Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice
Keywords: Cx43; Nav1.5; Heterogeneity; Sodium current; ArrhythmiaCVL, longitudinal conduction velocity; CVT, transversal conduction velocity; Cx43, connexin43; ERP, effective refractory period; INa, sodium current; LV, left ventricle; RV, right ventricle; VT, ventr
Escape capture bigeminy: Phenotypic marker of cardiac sodium channel voltage sensor mutation R222Q
Keywords: Sodium channel; SCN5A; Nav1.5; Mutation; Patch clamp; Voltage clamp; Bigeminy; AF; atrial fibrillation; EP; electrophysiological; WT; wild type;
Metabolic stress, reactive oxygen species, and arrhythmia
Keywords: âΨm; mitochondrial membrane potential; ACE; angiotensin converting enzyme; ADP; adenosine diphosphate; AF; atrial fibrillation; AngII; angiotensin II; AP; action potential; ATP; adenosine-5â²-triphosphate; [Ca2+]i; intracellular Ca2+ concentration; CI
Pathophysiology of the cardiac late Na current and its potential as a drug target
Keywords: ATX-II; anemonia sulcata toxin; AP-A,Q; anthopleurin A, Q; hERG; human Ether-a-go-go Related Gene, KV11.1; INaT; transient (T) Na+ current; INaL; late (L) Na+ current; LQT(3); Long QT syndrome (variant 3); STX; saxitoxin; TTX; tetrodotoxin; Late Na curren
Local signals with global impacts and clinical implications: Lessons from the plasma membrane calcium pump (PMCA4)
Keywords: PMCA; plasma membrane calcium/calmodulin dependent ATPase; SERCA; sarco/endoplasmic reticulum calcium ATPase; SPCA; secretory pathway calcium ATPase; PDZ; PSD 95, Drosophila Discs large protein and Zona occludens-1; MAGUK; membrane-associated guanylate ki
Ankyrin-based cellular pathways for cardiac ion channel and transporter targeting and regulation
Keywords: Ankyrin; Nav1.5; Intercalated disc; Transverse-tubule; Arrhythmia; Sodium channel; Targeting
Role of Late Sodium Channel Current in Arrhythmogenesis
Keywords: Late INa; Angina; Heart failure; Arrhythmias; Ischemia; Sodium channel; Nav1.5;
Non-anti-mitotic concentrations of taxol reduce breast cancer cell invasiveness
Keywords: Taxol; Tubulin; Cancer invasiveness; NaV1.5; Metastasis; MDA-MB-231; MDA-MB-468;
NaV1.5 sodium channels in a human microglial cell line
Keywords: Microglia; NaV1.5; Na+; Macrophages; Sodium channels; Glia
Gain-of-function mutation of Nav1.5 in atrial fibrillation enhances cellular excitability and lowers the threshold for action potential firing
Keywords: Arrhythmia; Fibrillation; Genetics; Nav1.5; SCN5A; Hyperexcitability; Electrophysiology; Atria; HL-1; Cardiomyocytes
Biophysical characterization of a new SCN5A mutation S1333Y in a SIDS infant linked to long QT syndrome
Keywords: Sudden infant death syndrome; Genetics; Na+ channel; Nav1.5; Long QT syndrome; SCN5A