کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8348278 | 1541719 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increased acyl ghrelin but decreased total ghrelin and unacyl ghrelin in Chinese Han people with impaired fasting glucose combined with impaired glucose tolerance
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کلمات کلیدی
OGTTHDL-CSFALDL-CHOMA-IRIFGT2DDBPLAPSBPAcyl ghrelinHbA1cINSIGTNGTVFAWHRUAGMatsuda Index120HOMA-β - HOMA-bOral glucose tolerance test - آزمون تحمل گلوکز خوراکیimpaired glucose tolerance - اختلال تحمل گلوکزImpaired fasting glucose - اختلال قندخون ناشتاMRI - امآرآی یا تصویرسازی تشدید مغناطیسیinsulin - انسولینnormal glucose tolerance - تحمل گلوکز طبیعیtriglyceride - تریگلیسریدMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیcomputed tomography - توموگرافی کامپیوتری یا سی تی اسکن یا مقطعنگاری رایانهایInsulin sensitivity - حساسیت به انسولینWaist circumference - دور کمرType 2 diabetes - دیابت نوع 2Fasting - روزه داریbody mass index - شاخص توده بدنBMI - شاخص توده بدنیdiastolic blood pressure - فشار خون دیاستولیکsystolic blood pressure - فشار خون سیستولیکhigh-density lipoprotein cholesterol - لیپوپروتئین پرچگالی یا اچدیالLipid accumulation product - محصول تجمع لیپیدInsulin resistance - مقاومت به انسولینvisceral fat area - منطقه چربی احشاءWaist-to-height ratio - نسبت دور کمر به ارتفاعGlycated hemoglobin - هموگلوبین گلیکوزیلهPre-diabetes - پیش دیابتtotal cholesterol - کلسترول تامLow-density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کمPlasma glucose - گلوکز پلاسما
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Increased acyl ghrelin but decreased total ghrelin and unacyl ghrelin in Chinese Han people with impaired fasting glucose combined with impaired glucose tolerance Increased acyl ghrelin but decreased total ghrelin and unacyl ghrelin in Chinese Han people with impaired fasting glucose combined with impaired glucose tolerance](/preview/png/8348278.png)
چکیده انگلیسی
We assessed the plasma acyl ghrelin (AG), unacyl ghrelin (UAG), and total ghrelin (TGhr) levels in Chinese adults with pre-diabetes and newly diagnosed diabetes mellitus (NDDM) after an oral glucose tolerance test (OGTT), and abdominal subcutaneous fat area and visceral fat area (VFA) were measured. Fasting AG level was increased in the impaired fasting glucose (IFG) combined with impaired glucose tolerance (IFGÂ +Â IGT) and NDDM groups. AG, UAG, and TGhr levels were significantly decreased post-OGTT, and the decrements of 30-min AG, UAG, and TGhr post-OGTT were not significantly different among groups. UAG and TGhr levels did not differ significantly among the normal glucose tolerance (NGT), IFG and NDDM groups, but they decreased obviously in the IFGÂ +Â IGT and impaired glucose tolerance (IGT) groups. The NDDM group had larger VFA than the NGT, IGT, and IFGÂ +Â IGT groups, even after adjustment for height, it was still larger than the NGT group. The factors such as dyslipidemia and obesity which are prone to develop insulin resistance (IR) and decrease insulin sensitivity (IS) were negatively correlated with UAG and TGhr, positively with AG/UAG, while no correlations with AG. In terms of evaluating IS and IR, AG/UAG ratio may be superior in AG concentration. Our findings suggest that relative sufficiency of AG, the deficiency of TGhr and UAG are already present in IFGÂ +Â IGT patients. We speculate that there is UAG resistance in severe hyperglycemia (diabetic state), which could produce elevated TGhr and UAG compared to IFGÂ +Â IGT group. In the development of T2D, increase of VFA could be the initiating factor, leading elevated AG, reduced UAG, IR, decreased IS, and finally hyperglycemia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 60, October 2014, Pages 86-94
Journal: Peptides - Volume 60, October 2014, Pages 86-94
نویسندگان
Li Huang, Yuzhen Tong, Fang Zhang, Qiu Yang, Daigang Li, Shugui Xie, Yi Li, Hongyi Cao, Lizhi Tang, Xiangxun Zhang, Nanwei Tong,