کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8348613 | 1541733 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo
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کلمات کلیدی
RPMIGamideECLHEPESFBSDMEMPBS4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid - 4- (2-hydroxyethyl) -1-piperazineethanesulfonic acidDulbecco's modified Eagle's medium - Medal of Eagle اصلاح شده DulbeccoAntisense - آنتیسنسenterochromaffin-like - انتروکرومافین مانندGray - خاکستریstandard error of the mean - خطای استاندارد میانگینCancer - سرطانfetal bovine serum - سرم جنین گاوPhosphate buffered saline - فسفات بافر شورSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیRoswell Park Memorial Institute medium - موسسه خاطرات Roswell Park mediumMouse - موشProgastrin - پروگاسترینCRC - کد افزونگی دورهای curie - کوریAmidated gastrin - گاسترین متصلGgly - گرگ
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo](/preview/png/8348613.png)
چکیده انگلیسی
Progastrin (PG) is processed into a number of smaller peptides including amidated gastrin (Gamide), non-amidated glycine-extended gastrin (Ggly) and the C-terminal flanking peptide (CTFP). Several groups have reported that PG, Gamide and Ggly are biologically active in vitro and in vivo, and are involved in the development of gastrointestinal cancers. CTFP is bioactive in vitro but little is known of its effects in vivo. This study investigated the bioactivity of CTFP in vivo in normal tissues using gastrin deficient (GASKO) mice and in two mouse models of cancer (SCID mice bearing xenograft tumors expressing normal or knocked-down levels of gastrin and a mouse model of hepatic metastasis). As with Ggly, CTFP treatment stimulated colonic proliferation in GASKO mice compared to control. CTFP also significantly increased apoptosis in the gastric mucosa of male GASKO mice. CTFP did not appear to effect xenograft growth or the incidence of liver metastases. This is the first demonstration that CTFP has specific biological activity in vivo in the colon and stomach.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 46, August 2013, Pages 83-93
Journal: Peptides - Volume 46, August 2013, Pages 83-93
نویسندگان
Kathryn M. Marshall, Oneel Patel, Gianni Bramante, Marie Laval, Mildred Yim, Graham S. Baldwin, Arthur Shulkes,