کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8348643 | 1541733 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exenatide-loaded PLGA microspheres with improved glycemic control: In vitro bioactivity and in vivo pharmacokinetic profiles after subcutaneous administration to SD rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Exenatide-loaded PLGA microspheres with improved glycemic control: In vitro bioactivity and in vivo pharmacokinetic profiles after subcutaneous administration to SD rats Exenatide-loaded PLGA microspheres with improved glycemic control: In vitro bioactivity and in vivo pharmacokinetic profiles after subcutaneous administration to SD rats](/preview/png/8348643.png)
چکیده انگلیسی
A subcutaneous exenatide delivery system was developed and characterized in vitro and in vivo. The results clearly showed that the exenatide loaded PLGA microspheres prepared by using a non-aqueous processing medium had low burst release and high drug encapsulation efficiency. Exenatide loaded in the microspheres preserved its bioactivity. The pharmacokinetics parameters were determined after subcutaneous administration of microspheres to SD rats. The plasma concentration of the single dose of the sustained-release microspheres attained Cmax of 108.19 ± 14.92 ng/ml at tmax of 1.33 ± 0.58 h and the t1/2 was 120.65 ± 44.18 h. There was a linear correlation between the in vitro and in vivo release behavior (R2 = 0.888). Exenatide loaded microspheres may prove to have great potential for clinical use.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 46, August 2013, Pages 172-179
Journal: Peptides - Volume 46, August 2013, Pages 172-179
نویسندگان
Jiming Xuan, Yaling Lin, Jingbin Huang, Fei Yuan, Xiaoqing Li, Ying Lu, He Zhang, Junjie Liu, Zhiguo Sun, Hao Zou, Yan Chen, Jing Gao, Yanqiang Zhong,