Keywords: مشخصات فارماکوکینتیک; Fisetin; Geraldol; Drug delivery; Phytoconstituents; Pharmacokinetic profile;
مقالات ISI مشخصات فارماکوکینتیک (ترجمه نشده)
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Keywords: مشخصات فارماکوکینتیک; T1DM; type 1 diabetes; T2DM; type 2 diabetes; GIP; glucose-dependent Insulinotropic Polypeptides; DPP-IV; dipeptidyl peptidase-IV; PRDA; peptides red deer antlers; ACE; angiotensin converting enzyme; Peptides; Antidiabetic effects; Underlying mechanisms;
Keywords: مشخصات فارماکوکینتیک; Vanillic acid; Antinociceptive activity; Vascular permeability; Pharmacokinetic profile;
Keywords: مشخصات فارماکوکینتیک; extended release; hydrocodone; opioid; pharmacokinetic profile;
Positive modulation of α5 GABAA receptors in preadolescence prevents reduced locomotor response to amphetamine in adult female but not male rats prenatally exposed to lipopolysaccharide
Keywords: مشخصات فارماکوکینتیک; MP-III-022; Neurochemistry; Pharmacokinetic profile; Cytokines; Preadolecence;
Benzamide derivatives and their constrained analogs as histamine H3 receptor antagonists
Keywords: مشخصات فارماکوکینتیک; Histamine H3 receptor; SAR; Pharmacokinetic profile; Receptor occupancy;
Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents
Keywords: مشخصات فارماکوکینتیک; PI3K; Cancer; SBDD; Molecular planarity; Solubility; Pharmacokinetic profile
Deglycosylation and absorption of marein, flavanomarein and taxifolin-7-O-β-D-glucopyranoside from capitula of Coreopsis tinctoria in rats and humans
Keywords: مشخصات فارماکوکینتیک; Coreopsis tinctoria; Flavonoid glycoside; Flavonoid aglycone; Pharmacokinetic profile; Deglycosylation; TDG; taxifolin-7-O-β-D-glucopyranoside; CCT; the capitula of Coreopsis tinctoria; CCTE; the extract of CCT; GIT; gastrointestinal tracts; AUC; the are
Design, synthesis and biological evaluation of novel 4-phenoxy-6,7-disubstituted quinolines possessing (thio)semicarbazones as c-Met kinase inhibitors
Keywords: مشخصات فارماکوکینتیک; Quinoline; (Thio)semicarbazone; Anti-tumor activity; c-Met kinase inhibitor; Pharmacokinetic profile; Xenograft mice model
Synthesis and biological evaluation of new [1,2,4]triazolo[4,3-a]pyridine derivatives as potential c-Met inhibitors
Keywords: مشخصات فارماکوکینتیک; Antitumor; c-Met inhibitors; Selectivity; Pharmacokinetic profile;
Pharmacokinetic profile and metabolite identification of yuanhuapine, a bioactive component in Daphne genkwa by ultra-high performance liquid chromatography coupled with tandem mass spectrometry
Keywords: مشخصات فارماکوکینتیک; Yuanhuapine; Pharmacokinetic profile; Metabolite identification; LC–MS/MS
Modification of a dihydropyrrolopyrimidine phosphoinositide 3-kinase (PI3K) inhibitor to improve oral bioavailability
Keywords: مشخصات فارماکوکینتیک; PI3K; Cancer; Solubility; Liver microsomal stability; Permeability; Molecular planarity; Pharmacokinetic profile;
Original ResearchPharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Encenicline, a Selective α7 Nicotinic Receptor Partial Agonist, in Single Ascending-dose and Bioavailability Studies
Keywords: مشخصات فارماکوکینتیک; α7 nicotinic acetylcholine receptor agonist; bioavailability; encenicline cognition; pharmacodynamics; pharmacokinetic profile;
Exenatide-loaded PLGA microspheres with improved glycemic control: In vitro bioactivity and in vivo pharmacokinetic profiles after subcutaneous administration to SD rats
Keywords: مشخصات فارماکوکینتیک; Exenatide; PLGA microspheres; Glycemic control; Subcutaneous administration; Pharmacokinetic profile;
Toxicity of daphnane-type diterpenoids from Genkwa Flos and their pharmacokinetic profile in rat
Keywords: مشخصات فارماکوکینتیک; Daphnane-type diterpenoids; Genkwa Flos; Toxicity; Pharmacokinetic profile;
Featured contentOriginal researchComparative Pharmacokinetic, Pharmacodynamic, Safety, and Tolerability Profiles of 3 Different Formulations of Epoprostenol Sodium for Injection in Healthy Men
Keywords: مشخصات فارماکوکینتیک; bioequivalence; epoprostenol; hemodynamics; pharmacokinetic profile; prostacyclin;
Quantitative determination of nebivolol from human plasma using liquid chromatography–tandem mass spectrometry
Keywords: مشخصات فارماکوکینتیک; Nebivolol; Liquid–liquid extraction; Pharmacokinetic profile; LC/MSMS; Bioavailability; Bioequivalence
PEGylation of interleukin-10 improves the pharmacokinetic profile and enhances the antifibrotic effectivity in CCl4-induced fibrogenesis in mice
Keywords: مشخصات فارماکوکینتیک; Interleukin-10; PEGylation; Pharmacokinetic profile; Liver fibrosis; Macrophage
Steady-State Pharmacokinetics of Once-Daily Cyclobenzaprine Extended Release: A Randomized, Double-Blind, 2-Period Crossover Study in Healthy Volunteers
Keywords: مشخصات فارماکوکینتیک; cyclobenzaprine; muscle spasm; once daily; pharmacokinetic profile; skeletal muscle relaxant; steady state
SAR of N-phenyl piperidine based oral integrin α5β1 antagonists
Keywords: مشخصات فارماکوکینتیک; Integrin α5β1; Antagonists; N-Phenyl piperidine; Stereoisomers; Pharmacokinetic profile;
Novel small molecule bradykinin B1 receptor antagonists. Part 1: Benzamides and semicarbazides
Keywords: مشخصات فارماکوکینتیک; Bradykinin B1; Antagonist; Oral bioavailability; Pharmacokinetic profile
Prediction of the aqueous solvation free energy of organic compounds by using autocorrelation of molecular electrostatic potential surface properties combined with response surface analysis
Keywords: مشخصات فارماکوکینتیک; Quantitative structure–property relationship (QSPR); Aqueous solvation free energies; Pharmacokinetic profile; Molecular surface electrostatic potentials; Nonlinear response surface analysis (RSA)
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: Orally bioavailable compounds
Keywords: مشخصات فارماکوکینتیک; 1,3-Thiazine; Cannabinoid receptor agonist; Oral bioavailability; CB1; CB2; Pain; Pharmacokinetic profile
Determination of nifedipine in human plasma and its use in bioequivalence study
Keywords: مشخصات فارماکوکینتیک; LC–MS; Nifedipine; Human plasma; Sustained-release tablets; Pharmacokinetic profile
Optimization and validation of a high-performance liquid chromatographic method with UV detection for the determination of ketoconazole in canine plasma
Keywords: مشخصات فارماکوکینتیک; Ketoconazole; RP-HPLC with UV detection; Canine plasma; Pharmacokinetic profile
Sensitive and simple liquid chromatographic method with ultraviolet detection for the determination of nifedipine in canine plasma
Keywords: مشخصات فارماکوکینتیک; Nifedipine; Liquid chromatography with ultraviolet detection; Canine plasma; Pharmacokinetic profile