کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8348795 | 1541736 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The hypothalamic POMC mRNA expression is upregulated in prenatally undernourished male rat offspring under high-fat diet
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کلمات کلیدی
Ob-RbTTRDIOOGTTCARTDOHaDDevelopmental origin of health and diseaseMPUINSRIUGRBATPOMCAgRPNPYtransthyretinPNDWhite adipose tissue - بافت چربی سفیدbrown adipose tissue - بافت چربی قهوه ایoral glucose tolerance - تحمل گلوکز خوراکیfetal - جنینpostnatal day - روز پس از زایمانlow protein diet - رژیم کم پروتئینMicroarray - ریزآرایهintrauterine growth retardation - عقب ماندگی رشد داخل رحمیPVN - مالیات بر ارزش افزودهAppetite regulation - مقررات اشتهاarcuate nucleus - هسته قوسparaventricular nucleus - هسته پروژسترویکagouti-related peptide - پپتید مرتبط با agoutidiet-induced obesity - چاقی ناشی از رژیم غذاییWAT - چیMaternal undernutrition - کمبود تغذیه مادرانControl - کنترلinsulin receptor - گیرنده انسولینNeuropeptide Y - یوروپروتئین Y
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The hypothalamic POMC mRNA expression is upregulated in prenatally undernourished male rat offspring under high-fat diet The hypothalamic POMC mRNA expression is upregulated in prenatally undernourished male rat offspring under high-fat diet](/preview/png/8348795.png)
چکیده انگلیسی
Epidemiological studies demonstrated that adverse environmental factors leading to intrauterine growth retardation (IUGR) and low birth weight may predispose individuals to increased risk of metabolic syndrome. In rats, we previously demonstrated that adult male IUGR offspring from prenatal 70% food-restricted dams throughout gestation (FR30) were predisposed to energy balance dysfunctions such as impaired glucose intolerance, hyperleptinemia, hyperphagia and adiposity. We investigated whether postweaning moderate high-fat (HF) diet would amplify the phenotype focusing on the hypothalamus gene expression profile. Prenatally undernourished rat offspring were HF-fed from weaning until adulthood while body weight and food intake were measured. Tissue weights, glucose tolerance and plasma endocrine parameters levels were determined in 4-month-old rats. Hypothalamic gene expression profiling of adult FR30 rat was performed using Illumina microarray analysis and the RatRef-12 Expression BeadChip that contains 21,792 rat genes. Under HF diet, contrary to C animals, FR30 rats displayed increased body weight. However, most of the endocrine disorders observed in chow diet-fed adult FR30 were alleviated. We also observed very few gene expression changes in hypothalamus of FR30 rat. Amongst factors involved in hypothalamic energy homeostasis programming system, only the POMC and transthyretin mRNA expression levels were preferentially increased under HF diet. Both elevated gene expression levels may be seen as adaptive mechanisms counteracting against deleterious effects of HF feeding in FR30 animals. This study shows that the POMC gene expression is a key target of long-term developmental programming in prenatally undernourished male rat offspring, specifically within an obesogenic environment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Peptides - Volume 43, May 2013, Pages 146-154
Journal: Peptides - Volume 43, May 2013, Pages 146-154
نویسندگان
Marie-Amélie Lukaszewski, Laura Butruille, Emmanuelle Moitrot, Valérie Montel, Anne Dickes-Coopman, Jean Lesage, Christine Laborie, Didier Vieau, Christophe Breton,