Keywords: ACC1; acetylcoenzyme A carboxylase 1; ASIP; agouti signaling protein; BETA2; transcription factor Beta 2; CYP7a1; cytochrome P450, family 7, subfamily a, polypeptide 1; cFOS; transcription factor C-fos; FASN; fatty acid synthase; FOXA2; forkhead box prote
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Keywords: AKT; protein kinase B; Ang II; angiotensin II; BRDN; bilateral renal denervation; BUN; blood urine nitrogen; Cr; creatinine; G6Pase; glucose-6-phosphatase; HFD; high-fat diet; HOMA-IR; homeostasis-model assessment of insulin resistance; HPLC; high-pressur
Keywords: ABCC8; ATP Binding Cassette Subfamily C Member 8; CAPN10; calpain 10; Cdkal1; Cdk5 regulatory associated protein 1-like 1; DM; diabetes mellitus; GLIS3; GLIS Family Zinc Finger 3; HMGA1; high mobility group A1; HNF1A; hepatocyte nuclear factor 1A; HNF1Î
Keywords: SCFAs; short-chain fatty acids; LDLR; low-density lipoprotein receptor; InsR; insulin receptor; AMPK; AMP-activated protein kinase; PCSK9; proprotein convertase subtilisin kexin 9; PTP1B; protein tyrosine phosphatase 1B; BBR; berberine; TC; total choleste
Keywords: ABCA1; ATP-binding cassette transporter 1; ABCG1; ATP Binding Cassette G1; AMPK; 5â²AMP-activated protein kinase; AP-1; activator protein 1; apo A-I; apolipoproteins A-I; AT; adipose tissue; CCK-1; cholecystokinin; CD; Crohn's disease; CVD; cardiovascula
Keywords: AD; Alzheimer's disease; T2DM; type II diabetes mellitus; Aβ; amyloid beta; NFT; neurofibrillary tangles; IR; insulin resistance; InsR; insulin receptors; IRS; InsR substrate; IGF; insulin growth factor; ICV; intracerebroventricular; STZ; streptozotocin;
Keywords: AgRP; agouti related protein; AUC; area under curve; CART; cocaine-amphetamines related transcript; ER; estrogen receptor; HOMA; homeostasis model assessment; HP; high phytoestrogen; HP-HF; high phytoestrogen-high fat; InsR; insulin receptor; ipGTT; i
Keywords: FLL cells; Fibroblast-like ligament cells; AS; Ankylosing spondylitis; HC; Healthy controls; IPA; Ingenuity pathway analysis; HADHB; Trifunctional enzyme subunit beta; ECHS1; Enoyl-CoA hydratase; ACSL4; Long-chain-fatty-acid-CoA ligase 4; ACADM; Medium-ch
Keywords: ACTB; actin, beta; ACOX1; acyl-CoA oxidase 1; ADCYAP1R1; adenylate cyclase activating polypeptide 1 receptor 1; ADIPOQ; adiponectin C1Q and collagen domain containing; ADIPOR1; adiponectin receptor 1; ADIPOR2; adiponectin receptor 2; ADRA2B; adrenergic re
Keywords: SNP; INS; INSR; TCF7L2; PPAR-γ;
Keywords: scFv; single-chain fragment variable; Fab; fragment antigen binding; PBMC; peripheral blood mononuclear cell; V; variable; VH; variable heavy chain; VL; variable light chain; Vκ; variable kappa light chain; Vλ; variable lambda light chain; PPE; periplas
Keywords: DS; danshen-shanzha; CVD; cardiovascular disease; IMT; intima-media thickness; TC; total cholesterol; TG; triglyceride; LDL-C; low-density lipoprotein-cholesterol; HDL-C; high-density lipoprotein-cholesterol; ILâ1β; interleukin-1β; NO; nitric oxide; 6
Effects of microRNAs on skeletal muscle development
Keywords: HDAC4; histone deacetylase 4; SRF; serum response factor; Pax3; paired box protein pax-3; Pax7; paired box protein pax-7; 3â²UTR; 3â² untranslated region; MEF2A; myocyte-specific enhancer factor 2A; Mef2d; myocyte-specific enhancer factor 2D; Myf5; myog
Pharmacological effects and potential therapeutic targets of DT-13
Keywords: ADP; adenosine diphosphate; Akt; protein kinsase B; ALT; alanine transaminase; APD; action potential duration; AST; aspartate transaminase; Atg; autophagocytosis associated protein; CCR5; C, C chemokine receptor type 5; CXCR4; C-X-C chemokine receptor typ
MicroRNAs link chronic inflammation in childhood to growth impairment and insulin-resistance
Keywords: ALS; acid-labile subunit; APC; antigen-presenting cell; CXCL2; chemokine (C-X-C motif) ligand 2; ESR; erythrocyte sedimentation rate; FGFR1; fibroblast growth factor receptor 1; FOXO1; Forkhed box O1; FOXP3; forkhead box P3; GH; growth hormone; GHR; growt
Evolution, regulation, and function of porcine selenogenome
Keywords: ACC; acetyl CoA carboxylase; AKT; protein kinase B; Cys; cysteine; DIO1; type 1 iodothyronine deiodinase; ER; endoplasmic reticulum; FAS; fatty acid synthase; FOXO1; forkhead box protein O1; GPX; glutathione peroxidase; INSR; insulin receptor; MIEN; migra
Association between insulin receptor gene exon 17 rs1799817 variant and risk of nonalcoholic fatty liver disease
Keywords: Insulin resistance; INS; INSR; Nonalcoholic fatty liver disease; Gene variant;
Data on the effect of miR-15b on the expression of INSR in murine C2C12 myocytes
Keywords: MicroRNAs; miR-15b; Myocyte; INSR; IRS-1;
Data on the expression and insulin-stimulated phosphorylation of IRS-1 by miR-96 in L6-GLUT4myc myocytes
Keywords: MicroRNAs; miR-96; Myocyte; IRS-1; INSR;
The INSR rs2059806 single nucleotide polymorphism, a genetic risk factor for vascular and metabolic disease, associates with pre-eclampsia
Keywords: Single nucleotide polymorphism; SNP; INSR; rs2059806; Pre-eclampsia;
Standardized Mori ramulus extract improves insulin secretion and insulin sensitivity in C57BLKS/J db/db mice and INS-1 cells
Keywords: AGE; advanced glycation end-products; CON; normal control; DBCON; diabetic control; FBG; fasting blood glucose; H&E; hematoxylin and eosin; HPLC; high-performance liquid chromatography; INSR; insulin receptor; MG; methylglyoxal; MRE; ethanolic extract of
MiR-1271 upregulated by saturated fatty acid palmitate provokes impaired insulin signaling by repressing INSR and IRS-1 expression in HepG2 cells
Keywords: microRNA; miR-1271; Saturated fatty acid; Palmitate; Insulin resistance; INSR; IRS-1; Akt2; v-akt murine thymoma viral oncogene homolog 2; C/EBPα; CCAAT/enhancer binding protein alpha; ER; endoplasmic reticulum; FOXQ1; forkhead box Q1; GPC3; glypican 3;
Inhibition of the Let-7 Family MicroRNAs Induces Cardioprotection Against Ischemia-Reperfusion Injury in Diabetic Rats
Keywords: AAR; area at risk; antimiR; antimicroRNA; C; control; DR; diabetic rat; GLUT4; glucose transporter type 4; IGF-1R; insulinlike growth factor-1 receptor; InsR; insulin receptor; IS; infarct size; L; lentivirus vectors with let-7 antimiR; LY; LY294002; miRN
Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics
Keywords: AC; adenylyl cyclase; ACTH; adrenocorticotropic hormone; AKAP; A-kinase anchor protein; AMP; 5â² adenosine monophosphate; AMPK; AMP-activated protein kinase; Arfgap1; ADP-ribosylation factor GTPase-activating protein 1; Arhgef2; Rho guanine nucleotide ex
miR-322 regulates insulin signaling pathway and protects against metabolic syndrome-induced cardiac dysfunction in mice
Keywords: miR; microRNA; HFD; high fat diet; CD; control diet; IGF-1; insulin growth factor-1; IGF1R; insulin growth factor-1 receptor; INSR; insulin receptor; SIRT4; sirtuin 4; CD1; cyclin D1; VSMC; vascular smooth muscle cell; FS; fractional shortening; LVESD; le
IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models
Keywords: Hepatocarcinogenesis; IGF 1 Receptor; Epi-Driver; Therapeutic Target; FC; fold change; GEMM; genetically engineered mouse model; HCC; hepatocellular carcinoma; IGF; insulin-like growth factor; IGF1R; insulin-growth factor 1 receptor; INSR; insulin recepto
GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles
Keywords: Girdin/GIV; PI3âKinase; Akt; Glucose transporter/GLUT4; Exoâ70; Exocyst complex; Exocytosis; IR; Insulin resistance; InsR; Insulin receptor; GEF; Guanine-nucleotide Exchange Factor; GSVs; GLUT4-storage vesicles; IRS1; insulin receptor substrate 1; Exo
Photoactivation of Dok1/ERK/PPARγ signaling axis inhibits excessive lipolysis in insulin-resistant adipocytes
Keywords: Akt; protein kinase B; Dex; dexamethasone; Dok1; downstream of tyrosine kinases-1; ERK1/2; extracellular signal-regulated kinase 1 and 2; ap2; fatty acid binding protein 4; IBMX; isobutylmethylxanthine; IRS; insulin receptor substrate; InsR; insulin recep
Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats
Keywords: ACC; acetyl-CoA carboxylase; Akt/PKB; protein kinase B; AMPK; adenosine monophosphate-activated protein kinase; ANOVA; analysis of variance; CNS; central nervous system; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HRP; horseradish peroxidase; IKK; IÎ
Agile delivery of protein therapeutics to CNS
Keywords: Aβ; amyloid β; Ab-InsR; antibodies against insulin receptor; Ab-TfR; antibodies against transferrin receptor; AD; Alzheimer's disease; Aerosol OT; bis-(2-ethylhexyl) sulfosucciate; ALS; amyotrophic lateral sclerosis; ApoB; apolipoprotein B; ApoE; apolip
The hypothalamic POMC mRNA expression is upregulated in prenatally undernourished male rat offspring under high-fat diet
Keywords: DOHaD; developmental origin of health and disease; C; control; FR30; offspring from 70% food-restricted pregnant dams; IUGR; intrauterine growth retardation; MPU; maternal prenatal undernutrition; LP; low protein diet; WAT; white adipose tissue; BAT; brow
Polymorphisms in the IRSâ1 and PPAR-γ genes and their association with polycystic ovary syndrome among South Indian women
Keywords: PCOS; polycystic ovary syndrome; IRS-1; insulin receptor substrate-1; PPAR-γ; peroxisome proliferator-activated receptor-γ; T2DM; type-2 diabetes mellitus; TZD; thiazolidinediones; INSR; insulin receptor; ESHRE; European Society of Human Reproduction an
MDG-1, a polysaccharide from Ophiopogon japonicus exerts hypoglycemic effects through the PI3K/Akt pathway in a diabetic KKAy mouse model
Keywords: FFA; Free fatty acids; GLUT4; Glucose transport protein-4; GSK3β; Glycogen synthase kinase 3 beta; HDL-C; High density lipoprotein cholesterol; InsR; Insulin receptor; IRs-1; Insulin receptor substrate 1; LDL-C; low density lipoprotein cholesterol; OGTT;
Polymorphisms affecting micro-RNA regulation and associated with the risk of dietary-related cancers: A review from the literature and new evidence for a functional role of rs17281995 (CD86) and rs1051690 (INSR), previously associated with colorectal canc
Keywords: CD86; INSR; MiRNA; Colorectal cancer
Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK
Keywords: ALP; alkaline phosphatase; BMP; bone morphogenetic protein; Col1α1; collagen type I α1; CFU-M; colony forming cells by M-CSF; CTx-1; C-terminal telopeptide of type I collagen; Dkk1; Dickkopf 1; Dlx5; distal-less 5; GSH; glutathione; GSK3β; glycogen syn
Microarray analysis of gene expression changes in the brains of NR2B-induced memory-enhanced mice
Keywords: NR2B transgenic mice; microarray; gene expression profile; RyR; Homer-1c; AD; Alzheimer's diseases; CNS; central nervous system; CREB; cAMP response element-binding protein; ER; endoplasmic reticulum; FDR; false discovery rate; GAPDH; glyceraldehyde-3-pho
Replication of association of a novel insulin receptor gene polymorphism with polycystic ovary syndrome
Keywords: PCOS; INSR; replication; SNP;
Tissue Inhibitor of Metalloproteinase 3 Deficiency Causes Hepatic Steatosis and Adipose Tissue Inflammation in Mice
Keywords: EGFR; epidermal growth factor receptor; HFD; high-fat diet; Insr; insulin receptor; JNK; Jun-N-terminal kinase; MCP-1; monocyte chemotactic protein-1; NAFLD; nonalcoholic fatty liver disease; NO; nitric oxide; PPARγ; peroxisome proliferator-activated rec
Replication study of the insulin receptor gene in migraine with aura
Keywords: Migraine with aura; Insulin receptor gene; INSR; Association study
Two novel mutations in the insulin binding subunit of the insulin receptor gene without insulin binding impairment in a patient with Rabson–Mendenhall syndrome
Keywords: INSR; Rabson–Mendenhall syndrome; Leprechaunism; Hyperinsulinism; Insulin resistance; Donohue syndrome
No mutations detected in the INSR gene in a chromosome 19p13 linked migraine pedigree
Keywords: Migraine; INSR; Mutation; Variation; SNPMF1, migraine family 1; MO, migraine without aura; MA, migraine with aura; INSR, insulin receptor; SNP, single nucleotide polymorphism