کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8644765 | 1569768 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of microRNAs on skeletal muscle development
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کلمات کلیدی
ROCK1EZH2SMCsCDKN1AMyHCIRS1MEF2ACdc25aYY1PIK3R1HDAC4MyoDPax7INSRMyf5Myf6lin-28TGF-βPcGTGF-β1MPcsSRFMEF2DIGF-IIPAX3E2F33′ untranslated region - 3 منطقه غیر ترجمه3′UTR - 3'UTRMRFs - MRF هاSp1 - SP1transforming growth factor-β - تبدیل فاکتور رشد βTransforming growth factor-β1 - تبدیل فاکتور رشد β1enhancer of zeste homolog 2 - تقویت کننده یا ژنتیک همولوگ 2Myogenic differentiation - تمایز میوگنMyosin heavy chain - زنجیره سنگین میوزینinsulin receptor substrate 1 - زیر بغل گیرنده انسولین 1Skeletal muscle cells - سلول های عضلانی اسکلتیMuscle progenitor cells - سلولهای پیش گیاه عضلانیMyogenic Factor 5 - عامل فاکتور 5Myogenic regulatory factors - عوامل کنترل کننده Myogenicinsulin-like growth factor 2 - فاکتور رشد مانند انسولین 2serum response factor - فاکتور پاسخ سرمیSpecificity protein 1 - مشخصات پروتئین 1Histone deacetylase 4 - هیستون دیازکتیلاز 4polycomb group - گروه پلی کامبinsulin receptor - گیرنده انسولینYin Yang 1 - یین یانگ 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
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چکیده انگلیسی
MicroRNAs (miRNAs) are small (about 22 nucleotides) noncoding RNAs, which were highly conserved among mammals. They have ushered in a new era in molecular biology over twenty years. They can negatively regulate gene expression at the posttranscriptional level through the principle of complementary base pairing with the 3â² untranslated region (UTR) of their target mRNAs and induce their degradation. They involve in tissue morphogenesis, cellular processes like apoptosis, and major signaling pathways. Previous studies have promoted our understanding that miRNAs play an important role in myogenesis and have a big impact on muscle mass, muscle fiber type and muscle diseases. Many researchers have provided evidence of the involvement of muscle-specific and enriched miRNAs in the individual stages of skeletal muscle development as well as of their significant influence on muscle metabolism during quiescence, proliferation, differentiation and regeneration. Here, we focus on the microRNAs that related to the development of skeletal muscle. For example, some microRNAs are upregulated in differentiated skeletal muscle and can promote differentiation, like, miR-1, miR-24, miR-26a, miR-181 and miR-206. However, some microRNAs highly expressed in proliferating myoblasts, downregulated in differentiated and could inhibit differentiation, like MiR-221 and miR-222. Some others not only promote skeletal muscle proliferation, but also promote differentiation, like miR-214. Studying the miRNAs' regulatory mechanisms in skeletal development will help us know more about the knowledge of miRNAs in muscle developmental biology and make us learn more about involved signal pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 668, 20 August 2018, Pages 107-113
Journal: Gene - Volume 668, 20 August 2018, Pages 107-113
نویسندگان
J. Wang, L.Z. Yang, J.S. Zhang, J.X. Gong, Y.H. Wang, C.L. Zhang, H. Chen, X.T. Fang,