Keywords: Microbiota; Microglia; Vagal afferents; Food intake; BDNF; brain-derived neurotrophic factor; CCK; cholecystokinin; CNS; central nervous system; GDNF; glia-derived neurotrophic factor; GF; germ-free; GI; gastrointestinal; HF; high fat; IRS1; Insulin recep
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Keywords: Butein (PubChem CID: 5281222); Cardamonin (PubChem CID: 641785); 2â²,4â²-Dihydroxy-6â²-methoxy-3â²,5â²-dimethylchalcone (PubChem CID: 10424762); Flavokawain B (PubChem CID: 5356121); Hydroxysafflor Yellow A (PubChem CID: 6443665); Naringenin Chalcone
Keywords: AC; anthocyanidins; GIP; gastric inhibitory polypeptide; GLP-1; glucagon-like peptide-1; GTT; glucose tolerance test; HFD; high fat diet; 4-HNE; 4-hydroxynonenal; IKK; IκB kinase; IRS1; insulin receptor substrate-1; ITT; insulin tolerance test; JNK; c-ju
Keywords: 11β-HSD1; 11B-hydroxysteroid dehydrogenase-1; ACTH; adrenocorticotropic hormone; CRH; corticotropin-releasing hormone; DHAP; dihydroxyacetone phosphate; FFA; free fatty acids; HFCS; high-fructose corn syrup; IRS1; insulin receptor substrate 1; ICAM-1; in
Keywords: ABCC8; ATP Binding Cassette Subfamily C Member 8; CAPN10; calpain 10; Cdkal1; Cdk5 regulatory associated protein 1-like 1; DM; diabetes mellitus; GLIS3; GLIS Family Zinc Finger 3; HMGA1; high mobility group A1; HNF1A; hepatocyte nuclear factor 1A; HNF1Î
Keywords: 27-HC; 27-Hydroxycholesterol; 3PO; 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one; ABCG1; ATP-binding cassette subfamily G1; ACBA1; ATP-binding cassette subfamily A1; ACC1; Acetyl-Co-A carboxylase-1; AKAP4; A-kinase anchoring protein 4; ALDO; Aldolase; AM
Keywords: AGE; Advanced Glycation End products; ALDH2; aldehyde dehydrogenase 2; AngII; angiotensin II; BKCa; large conductance Ca2+-activated K+ channel; Ca2+; calcium; [Ca2+]c; cytosolic free Ca2+ concentration; CaD; caldesmon, CaM, calmodulin; cAMP; cyclic adeno
Keywords: ACTH; adrenocorticotropic hormone; AMH; anti-Mullerian hormone; FSH; follicle stimulating hormone; HgBA1; glycosylated hemoglobin; IRS1; insulin receptor substrate 1; LH; luteinizing hormone; NC-CAH; non-classical (adult onset) congenital adrenal hyperpla
Keywords: IMCL; Intramyocellular lipid; DAG; diacylglycerol; CPT1; carnitine palmitoyl transferase1; ACAT1; acetyl-CoA acetyltransferase1; FASN; fatty acid synthase; SUCLG1; succinyl-CoA ligase (synthetase); NF-kB; nuclear factor kappaB; TNFa; tumour necrosis facto
Keywords: KME; aqueous extract of Korean mistletoe; EMG; electromyography; FoxO1; forkhead box protein O1; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSK3; glycogen synthase kinase 3; IGF; insulin growth factor; IR; insulin receptor; IRS1; insulin receptor su
Keywords: β-AR; β-adrenergic receptor; 4-HNE; 4-hydroxynonenal; ACC; acetyl-coA carboxylase; ALT; alanine aminotransferase; AMPK; adenosine monophosphate-activated protein kinase; ANOVA; analysis of variance; AST; aspartate transaminase; ATGL; adipose triglycerid
Keywords: AIP2; apoptosis inhibitory protein 2; BCL2; B-cell lymphoma 2; CUS; chronic unpredictable stress; FST; forced swim test; GLP1; glucagon like peptide 1; GLUT4; glucose transporter type 4; HPA axis; hypothalamic-pituitary-adrenal axis; INSG1; insulin in
Keywords: NAFLD; nonalcoholic fatty liver disease; CVD; cardiovascular disease; NASH; nonalcoholic steatohepatitis; ALT; alanine aminotransferase; AST; aspartate aminotransferase; GGT; γ-glutamyltranspeptidase; PKC; protein kinase C; IRS1; insulin receptor substra
Keywords: CAT; catalase; C; control; CYP 2A6; cytochrome P450 2A6; FAS; fatty acid synthase; GPx; glutathione peroxidase; 4HNE; 4-hydroxy-2-nonenal; IRS1; insulin receptor substrate-1; MDA; malondialdehyde; NADPH; nicotinamide adenine dinucleotide phosphate-oxidase
Keywords: FLL cells; Fibroblast-like ligament cells; AS; Ankylosing spondylitis; HC; Healthy controls; IPA; Ingenuity pathway analysis; HADHB; Trifunctional enzyme subunit beta; ECHS1; Enoyl-CoA hydratase; ACSL4; Long-chain-fatty-acid-CoA ligase 4; ACADM; Medium-ch
Keywords: 5-aza-CdR; 5-aza-2â²-deoxycytidine; AML; acute myeloid leukemia; ANRIL; antisense non-coding RNA in the INK4 locus; CBP; CREB-binding protein; CDKN2A; Cyclin-Dependent Kinase Inhibitor 2A; CoREST; co-repressor for element-1-silencing transcription factor
Keywords: ENPP1; IRS1; TRIB3; Prospective study;
Keywords: ABCA1; ATP binding cassette transporter A1; Actb; beta-actin; ApoA-I; apolipoprotein A-I; B2m; beta-2 microglobulin; Cyp2E1; cytochrome P450 2E1; FXR; farnesoid X receptor; Gapdh; glyceraldehyde-3-phosphate dehydrogenase; GLUT1; glucose transporter 1; HDL
Keywords: IR; insulin receptor; IRS1; insulin receptor substrate-1; IGF-R; insulin growth factor receptor; EGF; epidermal growth factor; MMP; matrix metalloproteinase; RTK; receptor tyrosine kinase; NGF; nerve growth factor; Neu1; mammalian neuraminidase-1; 4-MUNAN
Keywords: BRAF; B-Raf protein; BRD4; bromodomain-containing protein 4; CDK6; cyclin-dependent kinase 6; ERBB1; epidermal growth factor receptor; ERG; ETS-family oncogenic transcription factor; ERK; extracellular signal regulated protein kinase; FOS; FBJ murine oste
An FBXO40 knockout generated by CRISPR/Cas9 causes muscle hypertrophy in pigs without detectable pathological effects
Keywords: FBXO40; CRISPR/Cas9; Muscle hypertrophy; Pig; IGF1; insulin-like growth factor-1; IRS1; insulin receptor substrate 1; WT; wild type; CSA; Cross-sectional area; PFF; Porcine fetal fibroblasts; SCNT; somatic cell nuclear transfer; PAM; protospacer-adjacent
Transcriptome analysis for identification of candidate genes related to sex determination and growth in Charybdis japonica
Keywords: C. japonica; Charybdis japonica; SSRs; simple sequence repeats; ORFs; open reading frames; E1; ubiquitin activating enzyme; E2; ubiquitin conjugating enzyme; E3; ubiquitin ligase; JHE; juvenile hormone esterase; STAT; signal transducer and activator of tr
Effects of microRNAs on skeletal muscle development
Keywords: HDAC4; histone deacetylase 4; SRF; serum response factor; Pax3; paired box protein pax-3; Pax7; paired box protein pax-7; 3â²UTR; 3â² untranslated region; MEF2A; myocyte-specific enhancer factor 2A; Mef2d; myocyte-specific enhancer factor 2D; Myf5; myog
Treatment of Dendropanax morbifera leaves extract improves diabetic phenotype and inhibits diabetes induced retinal degeneration in db/db mice
Keywords: Dendropanax morbifera; Type 2 diabetes mellitus; Retinal degeneration; Db/db mice; Glucose transporter; AMP-activated protein kinase; DLE; Dendropanax morbifera leaves extract; IGT; Impaired glucose tolerance; GK; glucokinase; PEPCK; phosphoenolpyruvate c
Redox signal-mediated TRPM2 promotes Ang II-induced adipocyte insulin resistance via Ca2+-dependent CaMKII/JNK cascade
Keywords: TRPM2; transient receptor potential melastatin 2; Ang II; angiotensin II; H2O2; hydrogen peroxide; ADPR; ADP-ribose; ACA; N-(p-amylcinnamoyl)anthranilic acid; NAC; N-acetylcysteine; RAS; renin-angiotensin system; AT1R; Ang II type 1 receptor blocker; ACEI
Association of Native American ancestry and common variants in ACE, ADIPOR2, MTNR1B, GCK, TCF7L2 and FTO genes with glycemic traits in Colombian population
Keywords: ACE; angiotensin converting enzyme; MTNR1B; melatonin receptor 1B; GCK; glucokinase; TCF7L2; transcription factor 7 Like 2; FTO; alpha-ketoglutarate dependent dioxygenase; OR; odds ratio; IR; insulin resistance; T2D; type 2 diabetes; MS; metabolic syndrom
Biased G protein-coupled receptor agonism mediates Neu1 sialidase and matrix metalloproteinase-9 crosstalk to induce transactivation of insulin receptor signaling
Keywords: GPCR; G-protein coupled receptor; 4MUNANA or 4-MU; 2â²-(4-methylumbelliferyl)-α-D-N-acetylneuraminic acid; OP; oseltamivir phosphate; MMP; matrix metalloproteinase; NMBR; neuromedin B receptor; BR2; bradykinin receptor; AT2R or AngIIR1; angiotensin II r
The Protective Effects of IGF-I against β-Amyloid-related Downregulation of Hippocampal Somatostatinergic System Involve Activation of Akt and Protein Kinase A
Keywords: AC; adenylyl cyclase; AD; Alzheimer's disease; Akt; protein kinase B; Aβ; beta-amyloid; BDNF; brain-derived neurotrophic factor; CCK; cholecystokinin, CRE, cyclic AMP response element; CREB; CRE-binding protein; GABA; γ-aminobutyric acid; GFAF; glial
(-)-Epicatechin and its metabolites prevent palmitate-induced NADPH oxidase upregulation, oxidative stress and insulin resistance in HepG2 cells
Keywords: Akt; protein kinase B; Apo; apocynin; DCDHF; 5-(and-6)-carboxy-2,7dichlorodihydrofluorescein; DCF; oxidized DCDHF; DNP; dinitrophenyl; DNPH; 2,4-dinitrophenylhydrazine; EC; (-)-epicatechin; ECM; (-)-epicatechin metabolites; 4-HNE; 4-hydroxynonenal; IKK; I
TAZ enhances mammary cell proliferation in 3D culture through transcriptional regulation of IRS1
Keywords: TAZ; IRS1; NT157; Hippo pathway; insulin signaling; spheroid formation;
PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Keywords: CRPC; castration-resistant prostate cancer; ADT; androgen deprivation therapy; PI3K; phosphoinositide 3-kinase; AR; androgen receptor; PTEN; phosphatase and tensin homologue deleted on chromosome 10; INPP4B; inositol polyphosphate 4-phosphatase type II; P
Disruption of tumor necrosis factor alpha receptor 1 signaling accelerates NAFLD progression in mice upon a high-fat diet
Keywords: High-fat diet; TNFR1; Nonalcoholic liver disease; IL-1 beta; Insulin resistance; Inflammation; IRS1;
Novel all-hydrocarbon stapled p110α[E545K] peptides as blockers of the oncogenic p110α[E545K]-IRS1 interaction
Keywords: Protein-protein interaction; p110α[E545K]; IRS1; Stapled peptide; % α-helicity; Proteolytic stability; AKT phosphorylation; Anti-cancer therapeutic;
Epigallocatechin-3-gallate inhibits adipogenesis through down-regulation of PPARγ and FAS expression mediated by PI3K-AKT signaling in 3T3-L1 cells
Keywords: 4E-BP1; 4E-binding protein1; C/EBP; CCAAT/ enhancer binding proteins; EGCG; epigallocatechin-3-gallate; FAS; fatty acid synthase; FOXO1; forkhead box-O1; HFD; high fat diet; IGF; insulin-like growth factor; IR; insulin resistance; IRS1; insulin receptor s
Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice
Keywords: High glucose; Oxidative stress; Vitamin D; SIRT1/AMPK/IRS1/GLUT4; Glucose metabolism; 1,25(OH)2D3; 1,25-dihydroxyvitamin D3; AKT; serine/threonine protein kinase; AMPK; AMP activated protein kinase; GLUT1; glucose transporter 1; GLUT4; glucose transporter
IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells
Keywords: ATF6; activating transcription factor 6; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; HNF4α; hepatocyte nuclear factor 4α; GAP; GTPase-activating protein; HFD; high fat diet; IL-4; interleukin-4; IRE1α; inositol-requiring enzyme 1
Steroidogenic acute regulatory protein (StAR) overexpression attenuates HFD-induced hepatic steatosis and insulin resistance
Keywords: StAR; steroidogenic acute regulatory protein; NAFLD; non-alcoholic fatty liver disease; HFD; high-fat diet; DMEM; Dulbecco's Modified Eagle Medium; PBS; phosphate buffered solution; FBS; fetal bovine serum; ITS-X; insulin-transferrin-selenium-ethanolamine
Essential role of protein kinase R antagonism by TRS1 in human cytomegalovirus replication
Keywords: Cytomegalovirus; PKR; Translation; Double-stranded RNA; TRS1; IRS1; Host defense;
Effect of dehydroepiandrosterone (DHEA) on Akt and protein kinase C zeta (PKCζ) phosphorylation in different tissues of C57BL6, insulin receptor substrate (IRS)1â/â, and IRS2â/â male mice fed a high-fat diet
Keywords: Dehydroepiandrosterone; Liver; Akt; IRS1; IRS2;
Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3β phosphorylation
Keywords: Simvastatin; Glucose uptake; Glucose transporter 4; IR-Dependent IRS-1/PI3K/Akt pathway; L6 myotubes; FPP; farnesyl pyrophosphate; FTI; farnesyltransferase inhibitor; GGPP; geranylgeranyl pyrophosphate; GGTI; geranylgeranyltransferase 1 inhibitor; GLUT4;
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
Keywords: 4E-BP1; 4E binding protein; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; ATP; adenosine triphosphate; DEPTOR; DEP domain containing mTOR-interacting protein; CI; complexes I; CII; complex II; CIII; complex III; CIV; complex
Interleukin-6 influences stress-signalling by reducing the expression of the mTOR-inhibitor REDD1 in a STAT3-dependent manner
Keywords: HIF; Hypoxia-inducible Factor; IL-6; Interleukin 6; IRS1; Insulin Receptor Substrate 1; Jak; Januskinase; mTOR; Mammalian Target of Rapamycin; MEF; Mouse Embryonic Fibroblast; NF-κB; Nuclear Factor kappa B; n.s.; non-significant; MAPK; Mitogen-Activated
Impaired adipose tissue lipid storage, but not altered lipolysis, contributes to elevated levels of NEFA in type 2 diabetes. Degree of hyperglycemia and adiposity are important factors
Keywords: Lipolysis; Type 2 diabetes; Adipose tissue; Metabolism; Lipid storage; ADRA2A; adrenoreceptor alpha 2 A; AT; Adipose tissue; FABP4; Fatty acid binding protein 4; FASN; Fatty acid synthase; IRS1; Insulin receptor substrate-1; GLUT4 and SLC2A4; Glucose tran
GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles
Keywords: Girdin/GIV; PI3âKinase; Akt; Glucose transporter/GLUT4; Exoâ70; Exocyst complex; Exocytosis; IR; Insulin resistance; InsR; Insulin receptor; GEF; Guanine-nucleotide Exchange Factor; GSVs; GLUT4-storage vesicles; IRS1; insulin receptor substrate 1; Exo
Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension in metabolic syndrome
Keywords: insulin resistance; IRS1; IRS2; NBCe1; proximal tubule; siRNA;
Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice
Keywords: DNL; de novo lipogenesis; IRS1; insulin-receptor-substrate 1; FB; fenofibrate; GTT; glucose tolerance test; β-HAD; β3-hydroxyacyl-CoA dehydrogenase; LCACoA; long chain acyl-CoA; DAG; diacylglycerol; GSK3β; glycogen synthase kinase; SREBP-1c; sterol reg
Adenomatous polyposis coli (APC)-induced apoptosis of HT29 colorectal cancer cells depends on mitochondrial oxidative metabolism
Keywords: APC; adenomatous polyposis coli; CDX2; caudal-related homeobox 2; COX; cytochrome c oxidase; CRC; colorectal cancer; DNP; 2,4-dinitrophenol; FAP; familial adenomatous polyposis; HT29 APCi; HT29 APC inducible; HT29 βGal; HT29 β galactosidase; IRS1; insul
Nymphayol increases glucose-stimulated insulin secretion by RIN-5F cells and GLUT4-mediated insulin sensitization in type 2 diabetic rat liver
Keywords: DM; diabetes mellitus; STZ; streptozotocin; NA; nicotinamide; NSFCExt; Nymphaea stellata flower chloroform extract; XRD; X-ray crystallography; IRS1; insulin receptor substrate-1; GLUT4; glucose transporter-4; G6PDH; glucose-6-phosphate dehydrogenase; G6P
Chitosan polyplex nanoparticle vector for miR-145 expression in MCF-7: Optimization by design of experiment
Keywords: miR-145; Chitosan; Design of experiment; miRNA; micro RNA; Mw; molecular weight; N/P; polymer amine to DNA phosphate ratio; RNAi; RNA interfering; siRNA; small interfering RNA; shRNA; short hairpin RNA; IGF-IR; type 1 insulin like growth factor receptor;
IRS1Ser307 phosphorylation does not mediate mTORC1-induced insulin resistance
Keywords: Diabetes; ER stress; mTORC1; IRS1;