کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8525966 | 1557945 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacological effects and potential therapeutic targets of DT-13
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کلمات کلیدی
Heme oxygenase-1IDHVCAM-1APDNrf2HO-1mTORCCR5ICAM-1EGFRERKTCMIRS-1ALTHUVECCXCR4ATGADPDPPHNF-κBPI3KMMPNuclear Factor- κBINSRDT-13JnkHIF-αnuclear factor erythroid 2Phorbol-12-myristate-13-acetatePCLEGR2,2-diphenyl-1-picrylhydrazyl - 2،2-دی فینیل-1-پریکیل هیدرازیلc-Jun N-terminal kinase - C-Jun N-terminal kinasePMA - LDC هاMAPK - MAPKPCA - PCATNF- α - TNF-αadenosine diphosphate - آدنوزین دی فسفاتAST - آسپارتات ترانس آمینازalanine transaminase - آلانین ترانس آمینازAkt - آکتPharmacological effects - اثرات فارماکولوژیکinsulin receptor substrate-1 - انسولین گیرنده زیربخش 1interleukin - اینترلوکینaspartate transaminase - ترانس آمیناز آسپارتاتtumor necrosis factor-α - تومور نکروز عامل αSOD - سدHuman umbilical vein endothelial cells - سلول های اندوتلیالی ورید ناف انسانEndothelial cells - سلولهای اندوتلیالSuperoxide dismutase - سوکسوکس دیسموتازextracellular signal regulated kinase - سیگنال خارج سلولی kinase را تنظیم می کندAnti-metastasis - ضد متاستازAnti-cancer - ضدسرطانtraditional Chinese medicine - طب سنتی چینیTissue factor - عامل بافتVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)phosphoinositide 3-kinase - فسفینوزیتید 3-کینازintradialytic hypotension - فشار خون داخل بینیlactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH matrix metalloproteinase - ماتریکس متالوپروتئینازAction potential duration - مدت زمان بالقوه عملintercellular adhesion molecule-1 - مولکول چسبندگی بین سلولی -1vascular cell adhesion molecule-1 - مولکول چسبندگی سلولی عروقی-1C-X-C chemokine receptor type 4 - نوع گیرنده شیمیایی C-X-C 4Mechanistic target of rapamycin - هدف مکانیکی رپامایسینearly growth response - پاسخ رشد اولیهmitogen activated protein kinase - پروتئین کیناز فعال Mitogen فعال استhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کاراPicryl chloride - کلرید پیکریلinsulin receptor - گیرنده انسولینEpithelial growth factor receptor - گیرنده فاکتور رشد اپیتلیال
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
DT-13 is an isolated compound from Dwarf lillytruf tuber and currently among active research drugs by National Natural Science foundation of China for its several potential effects. The drug has been reported for its multiple pharmacological actions however no thorough review studies are available on it. Our present study is highlighting the pros and cons of DT-13 focusing on its potential pharmacological actions, therapeutic utilization and further exploration for novel targets. The drug possesses very low toxicity profile, quick onset and long duration of action with slow elimination that combinely makes it favorable for the clinical studies. In vivo and in vitro studies show that the drug regulates multiple cellular functions for its several pharmacological effects including, anti-adhesive effects via regulation of tissue factor and transforming growth factor; anti-migratory effects through indirect regulation of NM-IIA in the tumor microenvironment, Tissue factor, down-regulation of CCR5-CCL5 axis and MMP-2/9 inhibition; anti-metastatic effects via regulation of MMPs and tissue factor; pro-apoptotic effects by modulation of endocytosis of EGF receptor; anti-angiogenic effects via regulation of HIF-1α,ERK, Akt signalling and autophagy inducing characteristics by regulating PI3K/Akt/mTOR signalling pathway. In addition to anti-tumor activities, DT-13 has significant anti-inflammatory, cardioprotective, hepatoprotective and immunomodulating effects. Pharmaceutical dosage form and targeted drug delivery system for DT-13 has not been established yet. Moreover, DT-13, has not been studied for its action on brain, colorectal, hepatic, pancreatic, prostate and blood cancers. Similarly the effects of drug on carbohydrate and glucose metabolism is another niche yet to be explored. In some traditional therapies, crude drug from the plant is used against diabetic and neurological disorders that are not reported in scientific literature, however due to profound effects of DT-13 on blood and cerebral ischemic disorders, it is reasonable to hypothesize that there could be an association of DT-13 that require further exploration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 97, January 2018, Pages 255-263
Journal: Biomedicine & Pharmacotherapy - Volume 97, January 2018, Pages 255-263
نویسندگان
Ghulam Jilany Khan, Mohsin Rizwan, Muhammad Abbas, Muhammad Naveed, Yu Boyang, Muhammad Ahsan Naeem, Sara Khan, Shengtao Yuan, Mirza Muhammad Faran Ashraf Baig, Li Sun,