Keywords: ADA; American Diabetes Association; AUC; area under the curve; BMI; body mass index; CD; cluster of differentiation; CI; confidence interval; CRP; C-reactive protein; CV; cardiovascular; DSS-II; 2nd Diabetes Surgery Summit; ELISA; enzyme-linked immunosorb
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Keywords: Inflammation; Extracellular matrix; Immunology; Vascular biology; Atherosclerosis; CS; chondroitin sulfate; HCAEC; human coronary artery endothelial cells; EC; endothelial cell; MCP-1; monocyte chemotactic protein 1; PMA; phorbol-12-myristate-13-acetate;
Keywords: DCM; dichloromethane; DME; 1,2-dimethoxyethane; DMF; N,N-dimethylformamide; ESI; electrospray ionization; FTMS; fourier transform mass spectrometry; GLs; glucosinolates; HESI; heated electrospray ionization; HRMS; high resolution mass spectrometry; IR; in
Pharmacological effects and potential therapeutic targets of DT-13
Keywords: ADP; adenosine diphosphate; Akt; protein kinsase B; ALT; alanine transaminase; APD; action potential duration; AST; aspartate transaminase; Atg; autophagocytosis associated protein; CCR5; C, C chemokine receptor type 5; CXCR4; C-X-C chemokine receptor typ
Excessive interferon-α signaling in autoimmunity alters glycosphingolipid processing in B cells
Keywords: Autoimmunity; B cell; iNKT cell; Interferon-α; Glycosphingolipid; GSL metabolism; IFN; interferon; TNF; tumour necrosis factor; IL; interleukin; iNKT; invariant natural killer T; GSL; glycosphingolipid; Cer; ceramide; LacCer; lactosylceramide; GCS; gluco
A polysaccharide from Eclipta prostrata alleviates experimental autoimmune encephalomyelitis through inhibiting Th17 cells
Keywords: MS; multiple sclerosis; EAE; experimental autoimmune encephalomyelitis; H&E; hematoxylin & eosin; LFB; luxol fast blue; Th cells; T helper cells; ConA; concanavalin-A; TGF-β; transforming growth factor-beta; Ara; arabinose; Glc; glucose; Gal; galactose
Advanced glycation end products promote triple negative breast cancer cells via ERK and NF-κB pathway
Keywords: Advanced glycosylation end product; Breast cancer; Invasion; Migration; MMP-9; And NK-κB; AGEs; advanced glycation end products; ERK; extracellular-signal regulated kinase; JNK; c-jun kinase; MAPK; mitogen-activated protein kinase; MMP; matrix metallopro
Dexamethasone inhibits inflammatory response via down regulation of AP-1 transcription factor in human lung epithelial cells
Keywords: AP-1; activator protein; COX-2; cyclooxygenase-2; LPS; lipopolysaccharide; NF- κB; nuclear factor-kappa-B; NO; nitric oxide; PMA; phorbol-12-myristate-13-acetate; IL; interleukins; TNF-α; tumor necrosis factor - α; GREs; glucocorticoid responsive eleme
Sirtuin 3-induced macrophage autophagy in regulating NLRP3 inflammasome activation
Keywords: NLRP3; Nod-like receptor family, pyrin domain-containing 3; HAECs; human aortic endothelial cells; MCM; macrophage-conditioned medium; MnSOD; manganese superoxide dismutase; mtROS; mitochondrial reactive oxygen species; PMA; phorbol-12-myristate-13-acetat
Epothilone D inhibits microglia-mediated spread of alpha-synuclein aggregates
Keywords: α-syn; α-Synuclein; EpoD; Epothilone D; MSA; Multiple System Atrophy; PD; Parkinson's Disease; CNS; Central nervous system; DLB; Dementia with Lewy Bodies; LB; Lewy Bodies; GCI; Glial Cytoplasmic Inclusion; PMA; Phorbol-12-Myristate-13-Acetate; HAPI; Hi
The 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3â²,4â²-methylenedioxyphenyl]-coumarin downmodulates the FcγR- and CR-mediated oxidative metabolism and elastase release in human neutrophils: Possible mechanisms underlying inhibition of the formation a
Keywords: ABAH; 4-aminobenzoic acid hydrazide; ANOVA; analysis of variance; CL-luc; lucigenin-enhanced chemiluminescence; CL-lum; luminol-enhanced chemiluminescence; CR; complement receptor; DAPI; 4',6-diamidino-2-phenylindole dihydrochloride; DMSO; dimethyl sulfox
Development, phenotype, and function of non-conventional B cells
Keywords: ATA; anti T cell antigen; BCR; B cell receptor; IGHV; immunoglobulin heavy chain variable gene; LPS; lipopolysaccharide; MDA; malondialdehyde; MZ; marginal Zone; MFI; mean fluorescence intensity; N-nucleotide; non-template nucleotide; OVA; ovalbumin; PC;
Aberrant NKG2D expression with IL-17 production of CD4+ T subsets in patients with type 2 diabetes
Keywords: T2D; type 2 diabetes; NKG2D; the natural killer group 2, member D receptor; CD; cluster of differentiation; IL; interleukin; PMA; phorbol-12-myristate-13-acetate; TCR; T cell receptor; ND; non-diabetic individuals; HbA1c; glycated hemoglobin A1c; IFN-γ;
Structural analysis of ribosomal RACK1 and its role in translational control
Keywords: RACK1; Receptor for activated C-Kinase 1; rRNA; Ribosomal RNA; mRNA; Messenger RNA; PKC; Protein kinase C; eIF6; Eukaryotic initiation factor 6; eIF3; Eukaryotic initiation factor 3; eIF4E; Eukaryotic initiation factor 4E; Src; Sarcoma family kinase; Scp1
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects
Keywords: SIRT6; sirtuin 6; TNF-α; tumor necrosis factor; PBMC; peripheral blood mononuclear cell; SEB; staphylococcal enterotoxin B; PMA; phorbol-12-myristate-13-acetate; 2-NBDG; 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose; PDAC; pancreatic d
Davallia bilabiata exhibits anti-angiogenic effect with modified MMP-2/TIMP-2 secretion and inhibited VEGF ligand/receptors expression in vascular endothelial cells
Keywords: D. bilabiata; Davallia bilabiata; MMPs; matrix metalloproteinases; VEGF; vascular endothelial growth factor; VEGFR; vascular endothelial growth factor receptor; CAM; chorioallantoic membrane; TIMP; tissue inhibitor of metalloproteinase; RECK; reversion-in
Ugonin U stimulates NLRP3 inflammasome activation and enhances inflammasome-mediated pathogen clearance
Keywords: ASC; apoptosis-associated speck-like protein containing a caspase recruitment domain; [Ca2+]i; intracellular calcium concentration; DAMPs; danger-associated molecular patterns; IP3; inositol triphosphate; IP3R; inositol triphosphate receptor; LPS; lipopol
The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5
Keywords: PRMT5; protein arginine methyltransferase 5; EGFR; epidermal growth factor receptor; TNF; tumor necrosis factor; NF-Y; nuclear factor Y; PKC; protein kinase C; Hsp90; heat shock protein 90; UPS; ubiquitin-proteasome system; CHIP; carboxyl terminus of he
Immunomodulatory effects of individual and combined mycotoxins in the THP-1 cell line
Keywords: AOD; 2-amino-14,16-dimethyloctadecan-3-ol; AOH; alternariol; BSA; bovine serum albumin; CA; concentration addition; CRC; concentration-response curve; DON; deoxynivalenol; DSBs; DNA double stranded breaks; EC; effect concentration; ELISA; enzyme linked im
State-of-the-art on detoxification of Jatropha curcas products aimed for use as animal and fish feed: A review
Keywords: PE; phorbol esters; LOD; limit of detection; TPA; 12-O-tetradecanoylphorbol-13-acetate; PMA; phorbol-12-myristate-13-acetate; HPLC-UV; high-performance liquid chromatography-ultraviolet; LC/MS; liquid chromatography mass spectrometry; RNAi; RNA interfer
Synthesis of new 4-phenylpyrimidine-2(1H)-thiones and their potency to inhibit COX-1 and COX-2
Keywords: 4-Phenylpyrimidine-2(1H)-thiones; Inhibition of cyclooxygenases; BCS; biopharmaceutics classification system; CH3OH; methanol; COX; cyclooxy-genase; DMSO; dimethylsulfoxide; EDTA; ethylenediaminetetraacetic acid; EIA; enzyme immuno assay; ELISA; enzyme li
Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptors
Keywords: Neurosteroid; Protein kinase; Synaptic GABAA receptors; Extrasynaptic GABAA receptors; Phosphorylation; THDOC; tetrahydro-deoxycorticosterone; BIM-I; bisindolylmaleimide I; PMA; phorbol-12-myristate-13-acetate; THIP; 4,5,6,7-tetrahydroisothiazolo-[5,4-c]p
Treatment with recombinant tissue plasminogen activator (r-TPA) induces neutrophil degranulation in vitro via defined pathways
Keywords: AIS; acute ischemic stroke; ASPECTS; Alberta Stroke Program Early CT Score; ECASS; European Cooperative Acute Stroke Study; ELISA; enzyme-linked immunosorbent assays; HDL; high density lipoprotein; HI; hemorrhagic infarction; hsCRP; high sensitivity C-rea
Human megakaryocyte progenitors derived from hematopoietic stem cells of normal individuals are MHC class II-expressing professional APC that enhance Th17 and Th1/Th17 responses
Keywords: MKp; megakaryocyte progenitor; MK; megakaryocyte; MEP; bipotent megakaryocyte/erythroid-progenitor; HSPC; hematopoietic stem and progenitor cells; HSC; hematopoietic stem cell; Tpo; thrombopoietin; SCF; stem cell factor; pDC; plasmacytoid dendritic cell
Fascin actin bundling controls podosome turnover and disassembly while cortactin is involved in podosome assembly by its SH3 domain in THP-1 macrophages and dendritic cells
Keywords: Arp; actin-related protein; CORNb; anti-cortactin nanobody; DC; dendritic cells; EGFP; enhanced green fluorescent protein; FASNb; anti-fascin nanobody; GELNb; anti-gelsolin nanobody; GM-CSF; granulocyte macrophage colony-stimulating factor; HS1; hematopoi
OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity
Keywords: BiFC; bimolecular fluorescence complementation; ER; endoplasmic reticulum; FFAT; two phenylalanines in an acidic tract; GST; glutathione S-transferase; hyper-P; hyperphosphorylated; hypo-P; hypophosphorylated; LTP; lipid binding/transfer protein; MCS; mem
Mechanisms that underlie the internalization and extracellular signal regulated kinase 1/2 activation by PKR2 receptor
Keywords: AT1AR; angiotensin type 1A receptor; ConA; Concanavalin A; DN-GRK; dominant-negative G-protein-coupled receptor kinase 2; EGFP; enhanced green fluorescent protein; ERK; extracellular signal regulated kinase; GPCR; G-protein-coupled receptors; GRK; GPCR ki
A key role of the mitochondrial citrate carrier (SLC25A1) in TNFα- and IFNγ-triggered inflammation
Keywords: acetyl-CoA; acetyl-coenzyme A; ChIP; chromatin immunoprecipitation; CHX; cycloheximide; CIC; mitochondrial citrate carrier; CNFASB; 4-chloro-3-{[(3-nitrophenyl)amino]sulfonyl}benzoic acid; DAN; 2,3-diaminonaphthalene; FOXA1; forkhead-box A1; GAS; IFNγ-ac
Oxidative stress effect on progesterone-induced blocking factor (PIBF) binding to PIBF-receptor in lymphocytes
Keywords: DMSO; dimethylsulphoxide; FBS; fetal bovine serum; GP; generalized polarization; Id; liquid disordered; Io; liquid ordered; Lβ; gel phase; PIBF; Progesterone-Induced Blocking Factor; PMA; phorbol-12-myristate-13-acetate; ROS; reactive oxygen species.; Ly
N-truncation and pyroglutaminylation enhances the opsonizing capacity of Aβ-peptides and facilitates phagocytosis by macrophages and microglia
Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; APP; amyloid precursor protein; BSA; bovine serum albumin; CNS; central nervous system; DAMP; damage-associated molecular pattern; DAPI; 4â²,6-diamidino-2-phenylindole; E. coli; Escherichia coli; EDTA; ethylene
Visfatin contributes to the differentiation of monocytes into macrophages through the differential regulation of inflammatory cytokines in THP-1 cells
Keywords: DeM; differentiated macrophages; DiM; differentiating macrophages; ERK; extracellular signal-regulated kinase; FACS; fluorescence-activated cell sorter; FBS; fetal bovine serum; HRP; horseradish peroxidase; iNOS; inducible nitric oxide synthase; IL-1Ra; I
The PPARβ agonist L-165041 promotes VEGF mRNA stabilization in HPV18-harboring HeLa cells through a receptor-independent mechanism
Keywords: ARE; AU-rich element; CHX; cycloheximide; ELAV; Embryonic Lethal Abnormal Vision; ERK1/2; Extracellular signal Regulated Kinase1/2; HPV; Human Papillomavirus; HuR; Human antigen R; MAPK; Mitogen-Activated Protein Kinase; mTOR; mammalian Target Of Rapamyci
The PDZ-binding domain of syndecan-2 inhibits LFA-1 high-affinity conformation
Keywords: EGTA; ethylene glycol tetraacetic acid; HUVEC; human umbilical vein endothelial cell; ICAM-1; intercellular adhesion molecule 1; LFA-1; lymphocyte function-associated antigen 1; pLys; poly-d-lysine; PMA; phorbol-12-myristate-13-acetate; PtdIns[4,5]P2; pho
Regulation of chondrogenesis by protein kinase C: Emerging new roles in calcium signalling
Keywords: ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; ADSC; adipose-derived stem cell; ATP; adenosine triphosphate; BMP; bone morphogenic protein; cAMP; cyclic adenosine monophosphate; COMP; cartilage oligomeric matrix protein; CREB; cAM
T cell regulation in microgravity - The current knowledge from in vitro experiments conducted in space, parabolic flights and ground-based facilities
Keywords: 5-LOX; 5-lipoxygenase; AP-1; activator protein 1; APO; apoptosis antigen; BL; baseline; ConA; Concanavalin A; CREB; cAMP response element-binding protein; DLR; Deutsches Zentrums für Luft- und Raumfahrt, engl. German Aerospace Center; ESA; European Space
Cowpox virus but not Vaccinia virus induces secretion of CXCL1, IL-8 and IL-6 and chemotaxis of monocytes in vitro
Keywords: OPV; Orthopoxvirus; MPXV; Monkeypox virus; VACV; Vaccinia virus; CPXV; Cowpox virus; MVA; Modified Vaccinia Ankara virus; PMA; Phorbol-12-myristate-13-acetate; Orthopoxvirus; Cowpox virus; Chemokine; Chemotaxis; Monocyte;
CADM1 is expressed as multiple alternatively spliced functional and dysfunctional isoforms in human mast cells
Keywords: ASMCs; airway smooth muscle cells; CADM1; cell adhesion molecule 1; ECD; extracellular domain; HLMCs; human lung mast cells; LFs; lung fibroblasts; MCs; mast cells; PMA; phorbol-12-myristate-13-acetate; SP; alternatively spliced isoform; TSLC1; tumour sup
The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells
Keywords: DAG; diacylglycerol; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethylsulfoxide; ECL; enhanced chemiluminescence; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; GAP-43; growth associated
A report on anti-oedemogenic activity of Byttneria herbacea roots - Possible involvement of histamine receptor (type I)
Keywords: HBH; hydroalcoholic root extract of Byttneria herbacea; H1R; human histamine receptor type I; VEGF; vascular endothelial growth factor; LPS; lipopolysaccharide; HepG2; human hepatocellular liver carcinoma cell line; MTT; 3(4,5-dimethylthiazol-2-yl)-2,5-di
Retinoid metabolism and its effects on the vasculature
Keywords: ADH; alcohol dehydrogenase; ADMA; asymmetric dimethylarginine; AP-1; activated protein-1; apo14; β-apo-14â²-carotenal; ARVM; adult rat ventricular myocytes; ATBC; Alpha-tocopherol Beta-carotene Cancer Prevention Study; atRA; all-trans retinoic acid; BCO
Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages
Keywords: ATP; adenosine tri-phosphate; BPI-sf; brief pain inventory short form; CNS; central nervous system; GFAP; glial fibrillary acidic protein; GM-CSF; granulocyte macrophage colony stimulating factor; Iba-1; ionized calcium binding adaptor molecule 1; IC50; i
Internalization and induction of antioxidant messages by microvesicles contribute to the antiapoptotic effects on human endothelial cells
Keywords: Act D; actinomycin D; ATP; adenosine triphosphate; BSA; bovine serum albumin; CMH; 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine; Cu/Zn-SOD; copper/zinc superoxide dismutase; CUR61414; N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(piperazi
Differential activation of the inflammasome in THP-1 cells exposed to chrysotile asbestos and Libby “six-mix” amphiboles and subsequent activation of BEAS-2B cells
Keywords: Chrysotile asbestos; Libby six-mix amphiboles; Macrophage; IL-1β; Epithelium; ASC; apoptosis-associated speck-like protein containing a CARD; Chry; chrysotile; Cot; cancer osaka thyroid oncogene; DNPH; 2,4-dinitrophenylhydrazine; EMSA; electrophoretic mo
The third intracellular loop of D1 and D5 dopaminergic receptors dictates their subtype-specific PKC-induced sensitization and desensitization in a receptor conformation-dependent manner
Keywords: AC; adenylyl cyclase; Bmax; maximal binding capacity; BSA; bovine serum albumin; β2-AR; β2-adrenergic receptor; CA; [3H]-cAMP formed; CT; cytoplasmic tail; DA; dopamine; DMSO; dimethyl sulfoxide; EL3; third extracellular loop; EC50; effective concentrat
The expression of CD25, CD11b, SWC1, SWC7, MHC-II, and family of CD45 molecules can be used to characterize different stages of γδ T lymphocytes in pigs
Keywords: BAL; bronchoalveolar lavage; BM; bone marrow; GF; germ-free; IL-2; interleukin 2; MHC-II; major histocompatibility complex class II; MLN; mesenteric lymph nodes; PBS; phosphate buffered saline; PMA; phorbol-12-myristate-13-acetate; SWC1, SWC7; swine works
Extracellular ATP induces spikes in cytosolic free Ca2+ but not in NADPH oxidase activity in neutrophils
Keywords: [Ca2+]cyt; cytosolic Ca2+ concentration; DAG; diacyl glycerol; fMLP; N-Formyl-l-methionyl-l-leucyl-l-phenylalanine; HE; hydroethidine; HRP; horseradish peroxidase; PKC; protein kinase C; PB; peripheral blood; PMA; phorbol-12-myristate-13-acetate; ATP; Cal
Inhibition of protein kinase C decreases sensitivity of GABA receptor subtype to fipronil insecticide in insect neurosecretory cells
Keywords: CaMKinase II; calcium/calmodulin-dependent protein kinase II; DAG; diacylglycerol; DUM; Dorsal Unpaired Median; GABARs; gamma-aminobytiric acid receptors; Gö6983; 3-[1-[3-(dimethylamino) propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-d
Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel
Keywords: IRF-4; interferon regulatory factor-4; IFN; interferon; ISRE; IFN-stimulated response element; TCR; T-cell receptor; PMA; phorbol-12-myristate-13-acetate; I; Ionomycin; TAP; tandem affinity purification; IL-4; interleukin-4; HTLV-1; human adult T-cell leu
P2X7 receptor antagonists display agonist-like effects on cell signaling proteins
Keywords: DIDS; 4,4â²-diisothiocyano stilbene-2,2â²-disulfonic acid; CDCP1; CUB domain containing protein 1; BzATP; 2â²(3â²)-O-(4-Benzoylbenzoyl)adenosine 5â²-triphosphate; P2R; purinergic 2 receptor; PMA; phorbol-12-myristate-13-acetate; ERK; extracellular si
PKCdelta is a positive regulator of chondrogenesis in chicken high density micromass cell cultures
Keywords: Rottlerin; MEK-ERK; Sox9; shRNA; Cartilage formation; BMP; bone morphogenic protein; BSA; bovine serum albumin; CaM-KIII; calcium/calmodulin dependent protein kinase III; CMF-PBS; calcium/magnesium free PBS; DAG; diacyl-glycerol; DMMB; dimethyl-methylen