Inhibition of protein kinase C decreases sensitivity of GABA receptor subtype to fipronil insecticide in insect neurosecretory cells

► Among membrane receptors and/or ion channels targeted by insecticides, ionotropic γ-aminobutyric acid receptors (GABARs) are considered as vital complex protein subunits, mediating fast inhibitory transmission in the central nervous system. ► They are targeted by several important classes of insecticides, including cyclodienes (e.g. dieldrin) and phenylpyrazoles (e.g. fipronil). ► The present study demonstrates that insect GABARs are regulated by PKC and CaMKinase II. ► Furthermore, we have shown that inhibition of the PKC pathway decreases the fipronil sensitivity of GABAR subtype in insect neurosecretory cells.