Keywords: B859-35; (â) enantiomer of dihydropyrine 3-methyl-5-3-(4,4-diphenyl-1-piperidinyl)-propyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-piridine-3,5-dicarboxylate-hydrochloride (niguldipine); CAPP1-CaM; norchlorpromazine-CaM adduct; DMBA; 7,12-dimethylbenz
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Calcimycin induced IL-12 production inhibits intracellular mycobacterial growth by enhancing autophagy
Keywords: M. bovisBCG; Mycobacterium bovis BCG; M. tb; Mycobacterium tuberculosis; TB; Tuberculosis; P2RX7; Purinergic receptor P2X7; Atg; Autophagy-related gene; LC3; Microtubule-associated protein 1A/1B-light chain 3; 3-MA; 3-methyladenine; Baf-A1; Bafilomycin A1
Growth arrest and morphological changes triggered by emodin on Trypanosoma cruzi epimastigotes cultivated in axenic medium
Keywords: Trypanosoma cruzi epimastigotes; Emodin; Cytoskeleton; Protein kinase CK2; Tubulin; Cytokinesis; Chagas disease; 2,3-BPG; 2,3-bisphosphoglycerate; DRB; 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole; KN-62; 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-l-ty
Antidepressant-like effect of zinc is dependent on signaling pathways implicated in BDNF modulation
Keywords: BDNF; brain-derived neurotrophic factor; CAMKII; Ca2Â +/calmodulin-dependent protein kinase; CREB; cAMP response element binding protein; ERK; extracellular signal-regulated kinase; GSK-3; Glycogen synthase kinase 3; H-89; N-[2-(p-bromocinnamylamino) ethy
Structure-activity relationship studies of pyrimidine-2,4-dione derivatives as potent P2X7 receptor antagonists
Keywords: P2X7 receptor; Antagonists; KN-62; Structure-activity relationships; IL-1β; Inflammation; AcCl; acetyl chloride; ACN; acetonitrile; ATP; adenosine-5â²-triphosphate; BzATP; 2â²(3â²)-O-(4-benzoylbenzoyl)-ATP; DCM; dichloromethane; DMEM; Dulbecco's Mod
Subcellular distribution and early signalling events of P2X7 receptors from mouse cerebellar granule neurons
Keywords: ATP; adenosine 5â²-triphosphate; A-438079; 3-(5-(2,3-dichlorophenyl)-1 H-tetrazol-1-yl)methyl pyridine hydrochloride hydrate; BSA; bovine serum albumin; BBG; Brilliant Blue G; BzATP; 2â²-3â²-o-(4-benzoylbenzoyl)-adenosine 5â²-triphosphate; CNS; centra
Inhibition of protein kinase C decreases sensitivity of GABA receptor subtype to fipronil insecticide in insect neurosecretory cells
Keywords: CaMKinase II; calcium/calmodulin-dependent protein kinase II; DAG; diacylglycerol; DUM; Dorsal Unpaired Median; GABARs; gamma-aminobytiric acid receptors; Gö6983; 3-[1-[3-(dimethylamino) propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-d
Research ReportMg2+ ions reduce microglial and THP-1 cell neurotoxicity by inhibiting Ca2+ entry through purinergic channels
Keywords: oxATP; oxidized ATP; TNFα; tumor necrosis factor-alpha; BzATP; 2â²,3â²-[benzoyl-4-benzoyl]-ATP; UTP; uridine 5â²-triphosphate; KN-62; 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-l-tyrosyl]-4-phenylpiperazine]; MRS2179; N6-methyl-2'-deoxyadenosine-3',5
KN-62 analogues as potent differentiating agents of HL-60 cells
Keywords: Promyelocytic leukemia; Calmodulin-dependent protein kinases; KN-62; HL-60 cells; Differentiating agents
Contribution of two ionotropic purinergic receptors to ATP responses in submandibular gland ductal cells
Keywords: AEBSF; 4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride; BSA; bovine serum albumin; Bz-ATP; 2â²-3â²-O-(4-benzoylbenzoyl) adenosine 5â²-triphosphate; [Ca2+]i; intracellular concentration of calcium; EDTA; ethylene diamine tetraacetic acid; EGTA;
CD39-associated high ATPase activity contribute to the loss of P2X7-mediated calcium response in LCL cells
Keywords: ALL; acute lymphoblastic leukemia; AML; acute myelogenous leukemia; ATP; adenosine-5â²-triphosphate; BSA; bovine serum albumin; βγMeATP; β,γ-methylene ATP; BzATP; 2â²,3â²-O-(4-benzoylbenzoyl)-ATP; CML; chronic myelogenous leukemia; DEPC; diethylpyr