کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6597449 | 1423853 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Data on the effect of miR-15b on the expression of INSR in murine C2C12 myocytes
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Data on the effect of miR-15b on the expression of INSR in murine C2C12 myocytes Data on the effect of miR-15b on the expression of INSR in murine C2C12 myocytes](/preview/png/6597449.png)
چکیده انگلیسی
The ectopic expression of miR-15b is linked causally to impaired insulin signaling in human HepG2 hepatocytes through the suppression of INSR (Yang et al., 2015) [1]. In this data article, we further examined the effect of miR-15b on insulin signaling in a murine skeletal muscle cells, C2C12 myocytes. Although the 3'UTR of mouse INSR mRNA has an appropriate binding site for miR-15b based on TargetScan analysis, the ectopic expression of miR-15b did not suppress the expression and insulin-stimulated phosphorylation of insulin signaling intermediates in C2C12 myocytes. A more detailed understanding of the effects of miR-15b on hepatic insulin resistance can be found in “Obesity-induced miR-15b is linked causally to the development of insulin resistance through the repression of the insulin receptor in hepatocytes” (Yang et al., 2015) [1].
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Data in Brief - Volume 15, December 2017, Pages 882-886
Journal: Data in Brief - Volume 15, December 2017, Pages 882-886
نویسندگان
Won-Mo Yang, Kyung-Ho Min, Se-Whan Park, Wan Lee,