Modulation of the adaptive response to stress by brain activation of selective somatostatin receptor subtypes

► Brain activation of sst subtypes blunts various components of the stress response. ► Brain sst2/5 inhibits stress-induced CRF-ACTH release. ► Brain sst2 prevents stress-related anorexia and anxiogenic-like responses ► Brain sst5 suppresses stress-induced sympathetic activation and gastric stasis. ► Brain sst1 blocks stress-induced stimulation of colonic motor function.