High-dose versus low-dose octreotide in the treatment of acute pancreatitis: A randomized controlled trial

► We conducted a RCT to find an efficient octreotide regimen to prevent or treat SAP. ► No significant difference was between control and low-dose octreotide in efficacy. ► Compared to low-dose, high-dose octreotide efficiently reduce and attenuate SAP. ► Superior effect of high-dose was due to return of plasma SST to normal level. ► High-dose was also better in decreasing plasma level of IL-6 and TNF-α.