Bradykinin decreases nitric oxide release from microglia via inhibition of cyclic adenosine monophosphate signaling

► Bradykinin attenuated basal and LPS-induced NO production in BV2 microglial cells. ► A protein kinase A inhibitor mimicked the effects of Bradykinin, while cAMP elevating agents antagonized Bradykinin-mediated NO decrease. ► Moreover, Bradykinin inhibited the activation of cAMP responsive element binding protein expression. ► Bradykinin protected microglial cells from death triggered by a combination of LPS and each of the cAMP elevating agents. ► Gαi protein inhibitor abrogated the effects of BK on NO release, and the expression of Gαi protein in the plasma membrane was induced by BK.