کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8366647 | 1542680 | 2017 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Glucocorticoid treatment facilitates development of a metabolic syndrome in ovariectomized Macaca Mulatta fed a high fat diet
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کلمات کلیدی
TC, PPARγAUC, TG,LDL-C,Homeostatic model assessment of insulin resistance - ارزیابی مدل هومستاتیک مقاومت به انسولینtriglyceride - تریگلیسریدglucose transporter 4 - حمل کننده گلوکز 4cluster of differentiation 36 - خوشه تمایز 36high-fat diet - رژیم غذایی با چربی بالاMetabolic syndrome - سندرم متابولیکLeptin - لپتین rhesus monkey - میمون رزوسHemoglobin A1c - هموگلوبین A1cNon-human primates - پریماه غیر انسانیHDL-cholesterol - کلسترول HDLtotal cholesterol - کلسترول تامLow-density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کمPeroxisome proliferator-activated receptor gamma - گاما گیرنده گیرنده فعال پرولیفیزوم فعالGlucocorticoids - گلوکوکورتیکوئیدهاGlucocorticoid - گلوکوکورتیکوئیدها
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Metabolic syndrome (MetS) is characterized by a cluster of key features, which include abdominal obesity, insulin resistance, hypertension, and dyslipidemia. The aim of this study was to assess the impact of elevated glucocorticoid levels on the development of MetS in middle-aged female rhesus monkeys (Macaca Mulatta) after ovariectomy. Six female ovariectomized rhesus monkeys (9-13 years) were randomly assigned to either a control group (normal diet, n = 3) or a group in which MetS was facilitated (n = 3). The MetS group fed with HFD (15% fat) and received oral prednisone acetate treatment (50 mg/day). After 24 months, the GCs treatment was withdrawn with continuation of high-fat feeding for a further 12 months. After 24 months, the MetS group displayed a significant increase in body weight and abdominal circumference. Additionally, the MetS animals displayed abnormal serum lipids, insulin resistance and impaired glucose tolerance. Histology of liver biopsies indicated marked accumulation of lipid droplets in hepatocytes of MetS animals. Withdrawal of GCs treatment led to recovery from above-mentioned metabolic disorders. Whereas GCs treatment increased leptin expression, it lowered expression of adiponectin and other factors in adipose tissue. Expression of Hydroxy-steroid dehydrogenase-1 and glucose transporter type-4 in the livers of MetS animals were reduced. We conclude that in the context of high fat diet, high levels of exogenous GCs contribute to the development of MetS in non-human primates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 128, December 2017, Pages 105-113
Journal: Steroids - Volume 128, December 2017, Pages 105-113
نویسندگان
Linzhao Li, Guang Yang, Guangneng Liao, Jie Mei, Lan Li, Chengshi Wang, Yujia Yuan, Yujun Shi, Jingping Liu, Zhihui Zhong, Jingqiu Cheng, Yanrong Lu, Iain J. Clarke, Younan Chen,