کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8366747 1542697 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In human T cells mifepristone antagonizes glucocorticoid non-genomic rapid responses in terms of Na+/H+-exchange 1 activity, but not ezrin/radixin/moesin phosphorylation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
In human T cells mifepristone antagonizes glucocorticoid non-genomic rapid responses in terms of Na+/H+-exchange 1 activity, but not ezrin/radixin/moesin phosphorylation
چکیده انگلیسی
GCs stimulate a rapid non-genomic cp-ERM response in cells within 5 min. RU486 antagonized the GC-induced rapid decrease in NHE1 activity, and arrested PHA-stimulated T cells at G0/G1 phase but had no effect on the rapid increase in cp-ERM, which persisted for 24 h. However, the cp-ERM response was blocked by staurosporine in both resting and GC stimulated cells. The results of RU486 antagonized the GC induced rapid decrease in NHE1 ion transport activity, but not the increase cp-ERM. This suggests that RU486 in T cells exerts its antagonistic effects at NHE1 containing plasma membrane sites and not where cp-ERM links lipid rafts to cortical cytoskeletons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 111, July 2016, Pages 29-36
نویسندگان
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