A simple and convenient synthetic route to Ulipristal acetate

- We have succeeded in finding a new and efficient route for preparing Ulipristal acetate with a good yield.
- The ratio of the 5α,10α- and 5β,10β-epoxides was improved to 80:20.
- The yield of 11β-substituted isomer was greatly improved.
- The phenyl-sulfinyl compound 6 was successfully synthesized from ketone 5.
- These synthetic procedures are more suitable for industrial process.