Periodic solutions of angiogenesis models with time lags

To enrich the dynamics of mathematical models of angiogenesis, all mechanisms involved are time-dependent. We also assume that the tumor cells enter the mechanisms of angiogenic stimulation and inhibition with some delays. The models under study belong to a special class of nonlinear nonautonomous systems with delays. Explicit sufficient and necessary conditions for the existence of the positive periodic solutions were obtained via topological methods. Numerical examples illustrate our findings. Some open problems are presented for further studies.