کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8384025 | 1543461 | 2015 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mir-302c mediates influenza A virus-induced IFNβ expression by targeting NF-κB inducing kinase
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Little is known about the role of microRNA during influenza A virus (IAV) infection. We observed that NIK 3â²UTR luciferase activity was elevated during IAV infection. Further studies demonstrated that miR-302c reduced NIK expression, resulting in the reduction of IFNβ mRNA expression. We found that miR-302c prevented the translocation of NF-κB from the cytosol to the nucleus. Furthermore, IAV infection downregulated miR-302c expression, leading to the activation of IFNβ expression and the inhibition of viral replication. Compared to miR-302c, miR-520e cannot promote viral replication and production, although the two microRNAs target the same site of the NIK 3â²UTR. Collectively, our work defines a novel signaling pathway implicated in the control of IFNβ mRNA expression during IAV infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 24, Part B, 21 December 2015, Pages 4112-4118
Journal: FEBS Letters - Volume 589, Issue 24, Part B, 21 December 2015, Pages 4112-4118
نویسندگان
Shulin Gui, Xueyuan Chen, Mo Zhang, Fanpeng Zhao, Yushun Wan, Li Wang, Gang Xu, Li Zhou, Xin Yue, Ying Zhu, Shi Liu,