کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8384026 | 1543463 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Collagen XVI expression is upregulated in glioblastomas and promotes tumor cell adhesion
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The poor prognosis of glioblastoma patients is related to diffuse brain invasion and interaction of tumor cells with extracellular matrices (ECM). We describe expression and function of the FACIT-collagen XVI in glioblastomas. We found upregulation of collagen XVI mRNA as well as protein in glioblastomas as compared to normal cortex. SiRNA knockdown resulted in decreased cell adhesion whereas increased adhesion was observed on surfaces coated with collagen XVI. The migration of glioblastoma cells on this substrate remained unchanged. Our results demonstrate de-novo expression of collagen XVI in glioblastomas as part of the tumor specific remodeling of the ECM.Structured summaryMINT-6743179:Collagen IV (uniprotkb:P02462-1) and Collagen XVI (uniprotkb:Q07092) colocalize (MI:0403) by fluorescence microscopy (MI:0416)MINT-6743170:GFAP (uniprotkb:P14136) and Collagen XVI (uniprotkb:Q07092) colocalize (MI:0403) by fluorescence microscopy (MI:0416)
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issues 23â24, 15 October 2008, Pages 3293-3300
Journal: FEBS Letters - Volume 582, Issues 23â24, 15 October 2008, Pages 3293-3300
نویسندگان
Volker Senner, Sabine Ratzinger, Sonja Mertsch, Susanne Grässel, Werner Paulus,