کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8385286 | 1543689 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Peptidoglycan perception-Sensing bacteria by their common envelope structure
ترجمه فارسی عنوان
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کلمات کلیدی
GlcNAcmDAPMurNAcDisaccharideMeso-diaminopimelic acidPBPsPGNTCTLysMPRRTLRPAMPNODN-acetylmuramic acid - N-استیلیمورمیک اسیدLysin motif - انگیزه لیزینToll-like receptor - تیالآرImmune defence - دفاع ایمنیN-acetylglucosamine - نیتستیگلوکوزامینpenicillin binding proteins - پروتئین های مرتبط با پنی سیلینPeptidoglycan - پپتیدوگلیکانpattern recognition receptor - گیرنده شناسایی الگو
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
چکیده انگلیسی
Most Eubacteria possess peptidoglycan (PGN) or murein that surrounds the cytoplasmic membrane. While on the one hand this PGN sacculus is a very protective shield that provides resistance to the internal turgor and adverse effects of the environment, it serves on the other hand as a major pattern of recognition due to its unique structure. Eukaryotes harness this particular bacterial macromolecule to perceive (pathogenic) microorganisms and initiate their immune defence. PGN fragments are generated by bacteria as turnover products during bacterial cell wall growth and these fragments can be sensed by plants and animals to assess a potential bacterial threat. To increase the sensitivity the concentration of PGN fragments can be amplified by host hydrolytic enzymes such as lysozyme or amidase. But also bacteria themselves are able to perceive information about the state of their cell wall by sensing small soluble fragments released from its PGN, which eventually leads to the induction of antibiotic responses or cell differentiation. How PGN is sensed by bacteria, plants and animals, and how the antibacterial defence is modulated by PGN perception is the issue of this review.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Medical Microbiology - Volume 305, Issue 2, February 2015, Pages 217-223
Journal: International Journal of Medical Microbiology - Volume 305, Issue 2, February 2015, Pages 217-223
نویسندگان
Ute Bertsche, Christoph Mayer, Friedrich Götz, Andrea A. Gust,