کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8397094 | 1544159 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Local inflammatory reaction induced by Scolopendra viridicornis centipede venom in mice
ترجمه فارسی عنوان
واکنش التهابی موضعی ناشی از سم اسکولپندرا ورییدریکینس در موش سوری
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کلمات کلیدی
IL-6MCP-1IL-1βIL-8Scolopendra - اسکولپندراinterleukin 1 beta - اینترلوکین 1 بتاinterleukin 6 - اینترلوکین 6Interleukin 8 - اینترلوکین 8tumor necrosis factor alpha - تومور نکروز عامل آلفاTNF-α - فاکتور نکروز توموری آلفاInflammatory mediators - واسطه های التهابیLocal reaction - واکنش محلیEdema - ورمmonocyte chemoattractant protein-1 - پروتئین شیمیایی monocyte chemoattractant-1Keratinocyte chemoattractant - کراتینوسیت شیمیایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
چکیده انگلیسی
Centipede envenomation is generally mild, and human victims usually manifest burning pain, erythema and edema. Despite the abundance and ubiquity of these animals, centipede venom has been poorly characterized in literature. For this reason, the aim of this work was to investigate local inflammatory features induced by Scolopendra viridicornis centipede envenomation in mice, evaluating edema formation, leukocyte infiltration, production of inflammatory mediators, and also performing histological analysis. The highest edematogenic activity induced by the venom, determined by plethysmometry, was noticed 0.5 h after injection in mice footpad. At 24 h, edema was still detected in animals that received 15 and 60 μg of venom, and at 48 h, only in animals injected with 60 μg of venom. In relation to leukocyte count, S. viridicornis venom induced cell recruitment, mainly neutrophils and monocytes/macrophages, in all doses and time periods analyzed in comparison with PBS-injected mice. An increase in lymphocytes was detected especially between 1 and 24 h at 60 μg dose. Besides, eosinophil recruitment was observed mainly for 15 and 60 μg doses in early time periods. Edema formation and cell recruitment were also confirmed by histological analysis. Moreover, S. viridicornis venom stimulated the release of IL-6, MCP-1, KC, and IL-1β. Conversely, S. viridicornis venom did not induce the release of detectable levels of TNF-α. We demonstrated that the edematogenic activity induced by S. viridicornis venom was of rapid onset, and the venom stimulated secretion of pro-inflammatory mediators which contribute to the inflammatory reaction induced by S. viridicornis venom in an experimental model.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 76, 15 December 2013, Pages 239-246
Journal: Toxicon - Volume 76, 15 December 2013, Pages 239-246
نویسندگان
Louise Faggionato Kimura, José Pedro Prezotto-Neto, Bianca de Carvalho Lins Fernandes Távora, Marta Maria Antoniazzi, Irene Knysak, Samuel Paulo Gióia Guizze, Marcelo Larami Santoro, Katia Cristina Barbaro,