Bothropstoxin-I reduces evoked acetylcholine release from rat motor nerve terminals: Radiochemical and real-time video-microscopy studies

► The neuromuscular effects of a PLA2 from Bothrops snake venom were studied in vitro. ► The toxin reduces the neurotransmitter release and damages muscle fibers. ► It was concluded that both effects result from a membrane-destabilizing activity.