Phospholipase A2 activity-dependent and -independent fusogenic activity of Naja nigricollis CMS-9 on zwitterionic and anionic phospholipid vesicles

► Membrane-damaging activity of CMS-9 is associated with its fusogenicity. ► Anionic phospholipids elicit CMS-9-induced membrane fusion in a PLA2 activity-independent manner. ► CMS-9-induced fusion of zwitterionic phospholipid vesicles depends on PLA2 activity.