کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8398773 | 1544403 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mitophagy and the release of inflammatory cytokines
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
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چکیده انگلیسی
Mitophagy is a selective form of autophagy in which damaged or dysfunctional mitochondria are specifically targeted by autophagosomes for lysosomal degradation. Studies have demonstrated that loss of autophagy/mitophagy can lead to a build-up of cytosolic reactive oxygen species and mitochondrial DNA, which can, in turn, activate immune signalling pathways that ultimately lead to the releases of inflammatory cytokines, including IL-1α, IL-1β, IL-18, type I IFN and macrophage migration inhibitory factor (MIF). Moreover, release of these cytokines can subsequently promote the release of others, including IL-23 and IL-17. Thus, as well as being essential for normal cell homeostasis and mitochondrial health, mitophagy may represent an important regulatory mechanism controlling inflammatory responses in immune cells. This review discusses our current understanding of the mechanisms through which mitophagy regulates inflammatory cytokine release.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mitochondrion - Volume 41, July 2018, Pages 2-8
Journal: Mitochondrion - Volume 41, July 2018, Pages 2-8
نویسندگان
James Harris, Nadia Deen, Shahrzad Zamani, Md Abul Hasnat,