کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8401188 | 1544481 | 2014 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Images as drivers of progress in cardiac computational modelling
ترجمه فارسی عنوان
تصاویر به عنوان راننده پیشرفت در مدل سازی قلب محاسباتی
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کلمات کلیدی
فیزیولوژی قلب محاسباتی، تصویربرداری پزشکی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
چکیده انگلیسی
Computational models have become a fundamental tool in cardiac research. Models are evolving to cover multiple scales and physical mechanisms. They are moving towards mechanistic descriptions of personalised structure and function, including effects of natural variability. These developments are underpinned to a large extent by advances in imaging technologies. This article reviews how novel imaging technologies, or the innovative use and extension of established ones, integrate with computational models and drive novel insights into cardiac biophysics. In terms of structural characterization, we discuss how imaging is allowing a wide range of scales to be considered, from cellular levels to whole organs. We analyse how the evolution from structural to functional imaging is opening new avenues for computational models, and in this respect we review methods for measurement of electrical activity, mechanics and flow. Finally, we consider ways in which combined imaging and modelling research is likely to continue advancing cardiac research, and identify some of the main challenges that remain to be solved.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Biophysics and Molecular Biology - Volume 115, Issues 2â3, August 2014, Pages 198-212
Journal: Progress in Biophysics and Molecular Biology - Volume 115, Issues 2â3, August 2014, Pages 198-212
نویسندگان
Pablo Lamata, Ramón Casero, Valentina Carapella, Steve A. Niederer, Martin J. Bishop, Jürgen E. Schneider, Peter Kohl, Vicente Grau,