کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8429439 | 1546206 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Semaphorin 5A mediated cellular navigation: Connecting nervous system and cancer
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کلمات کلیدی
TSP-1IPTIL-8SEMA5ATGFGPiSemaphorin 5ACSPGCRDPSIRT-PCRECDNeuropilinsECMHSPGs - HSPG هاamino acid(s) - آمینو اسیدهاInterleukin-8 - اینترلوکین -8transforming growth factor - تبدیل فاکتور رشدextracellular domain - دامنه خارج سلولیcysteine rich domain - دامنه غنی از سیستینDevelopmental biology - زیست شناسی تکاملیCancer - سرطانSemaphorin - سمفورینExtracellular matrix - ماتریکس خارج سلولیreverse transcriptase polymerase chain reaction - واکنش زنجیره ای پلی مراز ترانس کریتاز معکوسheparan sulfate proteoglycans - پروپوگلیکان های سولفات heparanPlexins - پلکسین هاchondroitin sulfate proteoglycan - کندرویتین سولفات پروتئگلیکانglycophosphatidylinositol - گلیکوفسفیدیدیلینواستیل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The ultraprecise wiring of neurons banks on the instructions provided by guidance cue proteins that steer them to their appropriate target tissue during neuronal development. Semaphorins are one such family of proteins. Semaphorins are known to play major physiological roles during the development of various organs including the nervous, cardiovascular, and immune systems. Their role in different pathologies including cancer remains an intense area of investigation. This review focuses on a novel member of this family of proteins, semaphorin 5A, which is much less explored in comparison to its other affiliates. Recent reports suggest that semaphorins play important roles in the pathology of cancer by affecting angiogenesis, tumor growth and metastasis. We will firstly give a general overview of the semaphorin family and its receptors. Next, we discuss their roles in cellular movements and how that makes them a connecting link between the nervous system and cancer. Finally, we focus our discussion on semaphorin 5A to summarize the prevailing knowledge for this molecule in developmental biology and carcinogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1846, Issue 2, December 2014, Pages 485-493
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1846, Issue 2, December 2014, Pages 485-493
نویسندگان
Abhilasha Purohit, Anguraj Sadanandam, Pavan Myneni, Rakesh K. Singh,