کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8429455 | 1546208 | 2012 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Epithelial E- and P-cadherins: Role and clinical significance in cancer
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
E-cadherin and P-cadherin are major contributors to cell-cell adhesion in epithelial tissues, playing pivotal roles in important morphogenetic and differentiation processes during development, and in maintaining integrity and homeostasis in adult tissues. It is now generally accepted that alterations in these two molecules are observed during tumour progression of most carcinomas. Genetic or epigenetic alterations in E- and P-cadherin-encoding genes (CDH1 and CDH3, respectively), or alterations in their proteins expression, often result in tissue disorder, cellular de-differentiation, increased invasiveness of tumour cells and ultimately in metastasis. In this review, we will discuss the major properties of E- and P-cadherin molecules, its regulation in normal tissue, and their alterations and role in cancer, with a specific focus on gastric and breast cancer models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1826, Issue 2, December 2012, Pages 297-311
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1826, Issue 2, December 2012, Pages 297-311
نویسندگان
Joana Paredes, Joana Figueiredo, André Albergaria, PatrÃcia Oliveira, Joana Carvalho, Ana Sofia Ribeiro, Joana Caldeira, Ãngela Margarida Costa, Joana Simões-Correia, Maria José Oliveira, Hugo Pinheiro, Salomé S. Pinho, Rita Mateus, Celso A. Reis,