کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8430037 | 1546230 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Risk Factors for Severe Acute Graft-versus-Host Disease in Donor Graft Composition
ترجمه فارسی عنوان
عوامل خطر برای بیماری شدید حاد گاو - مقابل میزبان در ترکیب گاو اهدا کننده
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
Acute graft-versus-host disease (aGVHD) is 1 of the main major complications of post-hematopoietic stem cell transplantation (HSCT). Identifying patients at risk of severe aGVHD may lead to earlier intervention and treatment, resulting in increased survival and a better quality of life. We aimed to identify biomarkers in donor grafts and patient plasma around the time of transplantation that might be predictive of aGVHD development. We build on our previously published methods by using multiplex assays and multicolor flow cytometry. We identified 5 easily assessable cellular markers in donor grafts that combined could potentially be used to calculate risk for severe aGVHD development. Most noteworthy are the T cell subsets expressing IL-7 receptor-α (CD127) and PD-1. Additionally, we identified a potential role for elevated tumor necrosis factor-α levels in both graft and patient before HSCT in development of aGVHD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biology of Blood and Marrow Transplantation - Volume 24, Issue 3, March 2018, Pages 467-477
Journal: Biology of Blood and Marrow Transplantation - Volume 24, Issue 3, March 2018, Pages 467-477
نویسندگان
Arwen Stikvoort, Ahmed Gaballa, Martin Solders, Iris Nederlof, Björn Ãnfelt, Berit Sundberg, Mats Remberger, Mikael Sundin, Jonas Mattsson, Michael Uhlin,