کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8431212 | 1546258 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pretransplantation Minimal Residual Disease Predicts Survival in Patients with Mantle Cell Lymphoma Undergoing Autologous Stem Cell Transplantation in Complete Remission
ترجمه فارسی عنوان
پیش از پیوند با بیماری های باقی مانده حداقل انتظار می رود که بقای در بیماران مبتلا به لنفوم سلول مانتی که پیوند سلول های بنیادی اتولوگ را در رفع کامل
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کلمات کلیدی
لنفوم سلول انحصاری، پیوند حداقل بیماری باقی مانده، پیش بینی کنندگان، بقا،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
Autologous stem cell transplantation (ASCT) is standard therapy for mantle cell lymphoma (MCL) in remission after induction chemotherapy, with the best results for patients in complete remission (CR). We hypothesized that evaluation of minimal residual disease (MRD) before ASCT could further stratify outcomes for these patients. Patients with MCL who underwent ASCT in clinical CR between 1996 and 2011 with pretransplantation MRD testing were eligible. Presence of a clonal IgH rearrangement, t(11; 14) by PCR or positive flow cytometry from blood or bone marrow, was considered positive. An adjusted proportional hazards model for associations with progression-free (PFS) and overall survival (OS) was performed. Of 75 MCL patients in CR, 8 (11%) were MRD positive. MRD positivity was associated with shorter OS and PFS. The median OS for MRD-negative patients was not reached, with 82% survival at 5Â years, whereas for the MRD-positive patients, median OS was 3.01Â years (hazard ratio [HR], 4.04; PÂ = .009), with a median follow-up of 5.1Â years. The median PFS for MRD-negative patients was not reached with 75% PFS at 5Â years, whereas for MRD-positive patients, it was 2.38Â years (HR, 3.69; PÂ = .002). MRD positivity is independently associated with poor outcomes after ASCT for MCL patients in CR.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biology of Blood and Marrow Transplantation - Volume 22, Issue 2, February 2016, Pages 380-385
Journal: Biology of Blood and Marrow Transplantation - Volume 22, Issue 2, February 2016, Pages 380-385
نویسندگان
Andrew J. Cowan, Philip A. Stevenson, Ryan D. Cassaday, Solomon A. Graf, Jonathan R. Fromm, David Wu, Leona A. Holmberg, Brian G. Till, Thomas R. Chauncey, Stephen D. Smith, Mary Philip, Johnnie J. Orozco, Andrei R. Shustov, Damian J. Green,