کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8433591 | 1546540 | 2018 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
H2AFY is a novel fusion partner of MECOM in acute myeloid leukemia
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: H2AFY is a novel fusion partner of MECOM in acute myeloid leukemia H2AFY is a novel fusion partner of MECOM in acute myeloid leukemia](/preview/png/8433591.png)
چکیده انگلیسی
The MECOM gene encoding a zinc finger protein that functions as a transcription factor, was located on chromosome 3q26, and rearrangements of MECOM often cause its overexpression in acute myeloid leukemia (AML). We identified H2AFY as a novel fusion gene partner of MECOM in an elderly male AML patient with cryptic 3q26 rearrangement using the whole transcriptome sequencing, who carried out abnormal karyotype of 46,XY,t(3;5)(q27;q31),add(14)(p11). We validated the existence of the unreported H2AFY-MECOM fusion gene by RT-PCR and Sanger DNA sequencing, and detected mutations of NRAS and BCOR in this patient. In addition, we found abnormally elevated expression of MECOM in this patient by quantitative-polymerase chain reaction (RQ-PCR). Further research is needed to investigate functional characterizations of this novel fusion in the development of AML.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Genetics - Volumes 222â223, April 2018, Pages 9-12
Journal: Cancer Genetics - Volumes 222â223, April 2018, Pages 9-12
نویسندگان
Qiaoyan Han, Jiao Lu, Jianjiang Wang, Jinsong Ye, Xin Jiang, Haoyue Chen, Chunhua Liu, Lu Chen, Tong Lin, Suning Chen, Miao Sun, Feng Gao,