کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8434444 1546644 2018 42 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunotherapy for pancreatic cancer: A long and hopeful journey
ترجمه فارسی عنوان
ایمونوتراپی برای سرطان پانکراس: سفر طولانی و امیدوار کننده است
کلمات کلیدی
سرطان پانکراس، ایمونوتراپی، میکرو محیط زیست تومور، واکسن آنتیبادیهای مونوکلونال،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
Multiple therapeutic strategies have been developed to treat pancreatic cancer. However, the outcomes of these approaches are disappointing. Due to deeper understandings of the pivotal roles of the immune system in pancreatic cancer tumorigenesis and progression, novel therapeutic strategies based on immune cells and the tumor microenvironment are being investigated. Some of these approaches, such as checkpoint inhibitors, chimeric antigen receptor T-cell therapy, and BiTE antibodies, have achieved exciting outcomes in preclinical and clinical trials. The current review describes the roles of immune cells and the immunosuppressive microenvironment in the development of pancreatic cancer, as well as the preclinical and clinical outcomes and benefits of recent immunotherapeutic approaches, which may help us further disclose the mechanisms of pancreatic cancer progression and the dialectical views of feasibility and effectiveness of immunotherapy in treatment of pancreatic cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 425, 1 July 2018, Pages 143-151
نویسندگان
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