کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8434619 | 1546649 | 2018 | 51 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Non-apoptotic cell death in malignant tumor cells and natural compounds
ترجمه فارسی عنوان
مرگ سلولی غیر آپوپتوز در سلول های تومور بدخیم و ترکیبات طبیعی
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کلمات کلیدی
ترکیبات طبیعی، مرگ سلولی غیر آپوپتوزی، سرطان،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
Traditional cancer therapy is mainly targeting on enhancing cell apoptosis, however, it is well established that many cancer cells are chemo-resistant and defective in apoptosis induction. Therefore, it may have important therapeutic implications to exploit some novel natural compounds based on non-apoptotic programmed cell death. Currently, accumulating evidence shows that the compounds from nature source can induce non-apoptotic programmed cell death in cancer cells, and therefore these natural compounds have gained a great promise for the future anticancer therapeutics. In this review, we will concentrate our efforts on the latest developments regarding major forms of non-apoptotic programmed cell death--autophagic cell death, necroptosis, ferroptosis, pyroptosis, glutamoptosis and exosome-associated cell death. Our increased understanding of the role of natural compounds in regulating non-apoptotic programmed cell death will hopefully provide prospective strategies for cancer therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 420, 28 April 2018, Pages 210-227
Journal: Cancer Letters - Volume 420, 28 April 2018, Pages 210-227
نویسندگان
Jing Ye, Ruonan Zhang, Fan Wu, Lijuan Zhai, Kaifeng Wang, Mang Xiao, Tian Xie, Xinbing Sui,