Identifying molecular drivers of gastric cancer through next-generation sequencing

► Next-generation sequencing technology provides a powerful way to identify molecular drivers of gastric cancer. ► Targeted exome sequencing studies in gastric cancer reveal novel driver mutated genes such as ARID1A. ► Whole-transcriptome RNA sequencing identifies a critical role of AMPKα2 in the early stages of gastric cancer. ► The Cancer Genome Atlas is a highly valuable resource for understanding the molecular basis underlying this disease.