کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8444584 1547146 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interactions between MAP kinase and oestrogen receptor in human breast cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Interactions between MAP kinase and oestrogen receptor in human breast cancer
چکیده انگلیسی
This study confirms that ligand-mediated phosphorylation is associated with rapid nuclear localisation of ERα, due to oestrogen binding. ERα is phosphorylated at serine 118 in a ligand-independent manner. Preventing nuclear translocation of pMAPK reduced the levels of ligand-independent, but not ligand-dependent phosphorylation of ERα. Co-stimulation with both oestrogen and heregulin suggested that heregulin mediated signalling determines the subcellular localisation of ERα. Activation of ERα by direct phosphorylation may result in its rapid deactivation due to degradation or nuclear export.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 49, Issue 6, April 2013, Pages 1176-1186
نویسندگان
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