کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8449452 | 1547630 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The need for aminoglycosides in combination with β-lactams for high-risk, febrile neutropaenic patients with leukaemia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
The efficacy and safety of aminoglycosides given in combination with β-lactams for the treatment of febrile neutropaenia in patients with acute leukaemia or bone marrow transplantation was assessed using an evidence-based review of the literature with the aim to formulate treatment guidelines. These recommendations have been developed by an expert panel of the European Conference on Infections in Leukaemic patients (ECIL-1). We also present results of a questionnaire on current treatment practice in Europe. The expert panel concluded that β-lactam monotherapy is as efficacious as and less toxic than β-lactam-aminoglycoside combination therapy as empirical therapy. The choice of β-lactam should be based on local epidemiological data, antibiotic resistance patterns, recent β-lactam use and available evidence. Combination therapy should be reserved for patients presenting with severe sepsis or septic shock or for those with a high suspicion of resistant Gram-negative infections, pending susceptibility testing and institution of appropriate β-lactam monotherapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer Supplements - Volume 5, Issue 2, July 2007, Pages 13-22
Journal: European Journal of Cancer Supplements - Volume 5, Issue 2, July 2007, Pages 13-22
نویسندگان
Lubos Drgona, Mical Paul, Giampaolo Bucaneve, Thierry Calandra, Francesco Menichetti,