کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8452943 1547739 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hematopoietic stem cell transplantation for sickle cell disease: The changing landscape
ترجمه فارسی عنوان
پیوند سلول بنیادی هماتوپوئیدی برای بیماری سلول داسی شکل: چشم انداز در حال تغییر
کلمات کلیدی
انتقال خون مزمن، پیوند سلول بنیادی هماتوپوئیت، کم خونی سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
Allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative therapy for sickle cell disease (SCD); however, its use is limited by lack of suitable human leukocyte antigen (HLA)-matched donors and decreased application in older patients with significant morbidity. Myeloablative, HLA-identical sibling transplantation in children with SCD offers excellent long-term survival, with overall and event-free survival rates of 95% and 92%, respectively. However, the risk of graft-versus-host-disease, infections, infertility, and other long-term transplant complications, further limits its widespread use. Recent approaches using reduced intensity conditioning (RIC) are associated with lower toxicity, allowing extension of this modality to children and adults with significant morbidity; however, these approaches are also associated with increased risk of graft failure. The optimal RIC regimen that strikes the optimal balance between maximizing the rate of stable engraftment while minimizing transplant-related morbidity and mortality is unknown. Alternative donor transplants, most prominently, partial HLA-mismatched related transplants (haploidentical), are being investigated with promising initial results. This review will discuss long-term results of HLA-matched sibling HSCT for SCD, and recent updates on HLA-matched unrelated donor and unrelated umbilical cord blood HSCT for SCD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hematology/Oncology and Stem Cell Therapy - Volume 10, Issue 4, December 2017, Pages 259-266
نویسندگان
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