کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8453243 | 1547864 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chimeric antigen receptor (CAR) T cell therapy for malignant cancers: Summary and perspective
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
This paper will summarize the data obtained primarily from the last decade of chimeric antigen receptor (CAR) T cell immunotherapy. It will do so in a manner that provides an overview needed to set the foundation for perspective on the state of research associated with CAR T cell therapy. The topics covered will include the construction of engineered CAR T cells from the standpoint of the different generations, the mode in which autologous T cells are transfected, the various biomarkers that have been used in CAR T cell immunotherapy, and setbacks associated with engineered T cells. Perspective on priorities of CAR T cell immunotherapy will also be addressed as they are related to safety and efficacy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cellular Immunotherapy - Volume 2, Issue 2, November 2016, Pages 59-68
Journal: Journal of Cellular Immunotherapy - Volume 2, Issue 2, November 2016, Pages 59-68
نویسندگان
Aaron J. Smith, John Oertle, Dan Warren, Dino Prato,