کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8453362 | 1547880 | 2018 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The impact of the neutrophil:lymphocyte ratio in response and survival of patients with de novo diffuse large B-cell lymphoma
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The neutrophil:lymphocyte ratio (NLR) has emerged as prognostic in patients with hematological malignancies. We aimed at evaluating the NLR as predictive for complete response (CR) and prognostic for progression-free (PFS) and overall survival (OS) in a study cohort of 121 Peruvian patients with diffuse large B-cell lymphoma (DLCBL) treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). Patients with an NLR â¥6 (nâ¯=â¯28) were more likely to have a performance status ECOG â¥2 (74% vs. 23%; pâ¯<â¯0.001). NLR â¥6 was associated with lower CR rate to R-CHOP (46% vs. 74%; pâ¯=â¯0.02) and there was a trend towards significance in multivariate regression analyses (OR 0.36, 95% CI 0.11-1.00; pâ¯=â¯0.05). Patients with NLR â¥6 had lower 5-year PFS rate (39% vs. 72%; pâ¯<â¯0.001) and lower 5-year OS rate (46% vs. 75%; pâ¯=â¯0.001) than patients with NLR <6 and was an independent adverse factor for PFS (HR 2.43, 95% CI 1.21-4.87; pâ¯=â¯0.01) and OS (HR 2.68, 95% CI 1.31-5.47; pâ¯=â¯0.007) in multivariate Cox regression analyses. NLR â¥6 was prognostic of PFS and OS after adjusting for the International Prognostic Index and the NCCN-IPI scores. In conclusion, the NLR could add predictive and prognostic value to well established prognostic tools in DLBCL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 67, April 2018, Pages 82-85
Journal: Leukemia Research - Volume 67, April 2018, Pages 82-85
نویسندگان
Brady E. Beltrán, Sally Paredes, Esther Cotrina, Eduardo M. Sotomayor, Jorge J. Castillo,