کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8453512 1547911 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Essential thrombocytemia following immune thrombocytopenia with JAK2V617F mutation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Essential thrombocytemia following immune thrombocytopenia with JAK2V617F mutation
چکیده انگلیسی
JAK2V617F mutation is found in about 60% of cases of essential thrombocytemia (ET) and represents a driving mutation. Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a low platelet (PLT) count. So far, only 2 reports described ET following ITP. For the first time we analyzed in a patient the JAK2V617F allele burden at ITP onset occurred 13 years before the ET diagnosis and found the presence of a small clone JAK2V617F positive clone (3%) raised to 27% in the following years. The association of ET and ITP could suggest similar pathogenetic mechanisms that should be further investigated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research Reports - Volume 9, 2018, Pages 14-15
نویسندگان
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