Novel gene mutations in well-differentiated fetal adenocarcinoma of the lung in the next generation sequencing era

This report presents the first case with two novel gene mutations of the WDFA, suggesting that in addition to β-catenin, BRCA2 and TSC2 might play some important roles in up-regulation of Wnt signaling pathway. Moreover, use of NGS technique is helpful to understand the biology of this rare neoplasm and provide the potential gene for targeted therapy.