Keywords: Well-Differentiated fetal adenocarcinoma; β-catenin; CTNNB1; BRCA2; TSC2; NGS;
مقالات ISI (ترجمه نشده)
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Keywords: 5FU; 5-fluorouracil; 95%CI; 95% confidence interval; AA; amino acid; AFP; alpha fetoprotein; AML; actue myeloid leukemia; Ang2; angiopoietin 2; ATP; adenosine triphosphate; BCLC; Barcelona-Clinic Liver Cancer classification; BSC; best supportive care; CAP
Keywords: CT; computed tomography; FDG-PET/CT; fluorodeoxyglucose-positron emission tomography/computed tomography; MRI; magnetic resonance imaging; mTOR; mammalian target of rapamycin; OM; odontogenic myxoma; TS; tuberous sclerosis, also known as Bourneville-Pring
Keywords: ACL; ATP citrate lyase; AMPK; adenosine monophosphate kinase; ARG1; l-arginine-metabolizing enzyme arginase 1; BCAA; branched-chain amino acid; Bcl2; B-cell lymphoma 2; CAF; cancer-associated fibroblast; CIC; cancer-initiating cell; COX2; cytochrome oxida
Keywords: â¢OH; hydroxyl radical; 2,2-BP; 2,2-bipyridyl; ABC; ATP-binding cassette; AIF; apoptosis-inducing factor; AMPK; AMP-activated protein kinase; AMPKK; AMPK kinase; ANT; adenine nucleotide translocase; AP-1; activator protein 1; Apaf-1; protease activating
Keywords: KME; aqueous extract of Korean mistletoe; EMG; electromyography; FoxO1; forkhead box protein O1; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSK3; glycogen synthase kinase 3; IGF; insulin growth factor; IR; insulin receptor; IRS1; insulin receptor su
Keywords: AAA; ATPases associated with diverse cellular activities; 17-AAG; 17-N-allylamino-17-demethoxygeldanamycin; ABC; ATP-binding cassette; ABCE1; ATP binding cassette subfamily E member 1; AD; Alzheimer's disease; AIF; apoptosis inducing factor; Akt; Alpha se
Keywords: Tuberous sclerosis complex; TSC1; TSC2; Angiomyolipomas; West syndrome
Keywords: 4E-BP1; 4E-binding protein-1; AA; amino acid; ALS; autophagy-lysosomal system; AMPK; adenosine monophosphate-activated protein kinase; COPD; chronic obstructive pulmonary disease; CRP; C-reactive protein; ERK; extracellular signal regulated kinase; FFM; f
Strategies of biochemical adaptation for hibernation in a South American marsupial, Dromiciops gliroides: 2. Control of the Akt pathway and protein translation machinery
Keywords: 4EBP; eukaryotic translation initiation factor 4E-binding protein; Akt; protein kinase B; eIF2α; eukaryotic translation initiation factor 2A; eIF4e; eukaryotic translation initiation factor 4E; GSK-3α; glycogen synthase kinase 3 alpha; GSK-3β; glycogen
Liver Angiomyolipomas in Tuberous Sclerosis Complex-Their Incidence and Course
Keywords: tuberous sclerosis; mTOR; angiomyolipoma; mTOR inhibitors; everolimus; TSC1; TSC2;
In situ analysis of mTORC1/2 and cellular metabolism-related proteins in human Lymphangioleiomyomatosis
Keywords: ACSS2; acyl-coenzyme A synthetase short-chain family member 2; ATPB; β-F1-ATPase; BSM; bronchial smooth muscle; CPT1A; carnitine palmitoyltransferase 1A; ER; estrogen receptor; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GLS; glutaminase; GLUT1; glu
Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging
Keywords: Parkinson's disease; Autophagy; α-synuclein; FOXO1; SESN3; TSC2;
Deep phenotyping of patients with Tuberous Sclerosis Complex and no mutation identified in TSC1 and TSC2
Keywords: Deep phenotyping; Genotype-phenotype correlation; No mutation identified (NMI); Tuberous sclerosis complex (TSC); TSC1; TSC2;
Autophagy in ischemic stroke
Keywords: 3-MA; 3-methyladenine; Aβ; amyloid β; AIF; apoptosis-inducing factor; Akt; protein kinase B; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; Atg; autophagy-related genes; ATP; adenosine 5â²-triphosphate; BBB; blood-brain ba
Novel TSC1 and TSC2 gene mutations in Chinese patients with tuberous sclerosis complex
Keywords: Tuberous sclerosis complex; TSC1; TSC2; Point mutation; Diagnosis;
Development of hypomelanotic macules is associated with constitutive activated mTORC1 in tuberous sclerosis complex
Keywords: Hypomelanotic macules; mTOR; Silent substitution; TSC; TSC2;
Original ArticleAspirin disrupts the mTOR-Raptor complex and potentiates the anti-cancer activities of sorafenib via mTORC1 inhibition
Keywords: Aspirin; mTORC1; AMPK; Sorafenib; Proliferation; AMPK; Adenosine 5'-monophosphate (AMP)-activated protein kinase; mTOR; mammalian target of rapamycin; MEF; mouse embryonic fibroblast; TSC2; Tuberous sclerosis 1; NSAID; non-steroidal anti-inflammatory dr
Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation
Keywords: TSC1; TSC2; Human embryonic lung fibroblast cells;
Endothelial deletion of mTORC1 protects against hindlimb ischemia in diabetic mice via activation of autophagy, attenuation of oxidative stress and alleviation of inflammation
Keywords: 3-MA; 3-methyladenine; 3-NT; 3-nitrotyrosine; AI; apoptosis index, α-SMA, α-smooth muscle actin; bFGF; basic fibroblast growth factor; BM; bone marrow; CCK-8; cell counting kit-8; CLI; critical limb ischemia; DAPI; 49, 6-diamidino-2-phenylindole; DCFH-D
Recent progress in the identification of adenosine monophosphate-activated protein kinase (AMPK) activators
Keywords: ACC; acetyl-CoA carboxylase; ADaM; allosteric drug and metabolite; AID; auto-inhibitory domain; α-RIM; α-regulatory interacting motif; AMPK; adenosine monophosphate-activated protein kinase; ASMS; affinity selection mass spectrometry; CamKKβ; Ca2+/calm
Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-α-lipoic acid, in human hepatocellular carcinoma cells
Keywords: ACC; acetyl-CoA carboxylase; Akt; protein kinase B; AMPK; AMP-activated protein kinase; apoB; apolipoprotein B; apoE; apolipoprotein E; CPT1α; carnitine palmitoyltransferase 1α; DGAT1; diacylglycerol O-acyltransferase 1; DGAT2; diacylglycerol O-acyltran
Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK
Keywords: Ciclopirox; mTOR; AMPK; TSC2; Raptor;
Hepatitis B virus (HBV) X protein-mediated regulation of hepatocyte metabolic pathways affects viral replication
Keywords: HBV; Hepatitis B virus; HCC; Hepatocellular carcinoma; HBx; HBV X protein; cccDNA; Covalently closed circular DNA; ORF; Open reading frame; mTORC1; Mammalian target of rapamycin (mTOR) complex 1; TSC2; Tuberous-sclerosis complex-2; AMPK; AMP-activated pro
Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction
Keywords: AMPK; AMP-activated protein kinase; ATM; adipose tissue macrophages; CCL; chemokine (C-C motif) ligand; CCR2; chemokine (C-C motif) receptor 2; CX3CL1; chemokine (C-X3-C motif) ligand 1; CX3CR1; chemokine (C-X3-C motif) receptor; CXCL; CXC chemokine ligan
Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy
Keywords: SPC; sphingosylphosphorylcholine; I/R; ischemia/reperfusion; MTOR; mammalian target of rapamycin; MTORC1; mTOR complex 1; MTORC2; mTOR complex 2; MI; myocardial infarction; PI3K; phosphatidylinositol 3-kinase; TSC2; tuberous sclerosis complex 2; HUVECs; h
Regulation of mTORC1 by PI3K signaling
Keywords: insulin; TSC2; Rheb; Rag; Raptor; lysosome
Regulation of hippocampal synaptic plasticity by BDNF
Keywords: 4E-BPs; eIF4E-binding proteins; 5-HT; 5-hydroxytryptamine; ADF; actin-depolymerising factor; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; AMPA receptors; Arc; activity-regulated cytoskeleton-associated protein; BDNF; brain-derived n
MYC and metabolism on the path to cancer
Keywords: 2-DG; 2-deoxyglucose; 4E-BP; eIF4E-binding protein; 5,10-methylene THF; 5,10-methylenetetrahydrofolate; ACC; acetyl-CoA carboxylase; ACLY; ATP-citrate lyase; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; ChIP-seq; chromatin immunoprecip
RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; caRags; constitutively active Rags B and C; caRheb; constitutively active Rheb; caRhoA; constitutively active RhoA; mTOR; mechanistic target of rapamycin; mTORC; mechanistic target of rapamycin co
MicroRNA-451 regulates AMPK/mTORC1 signaling and fascin1 expression in HT-29 colorectal cancer
Keywords: AMPK; AMP-activated protein kinase; ACC; Acetyl-CoA Carboxylase; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; CAB39; calcium-binding protein 39; FSCN1; fascin1, mammalian target of rapamycin (mTOR); mTORC1; mTOR complex 1; Raptor; regulato
Activation of ERK by sodium tungstate induces protein synthesis and prevents protein degradation in rat L6 myotubes
Keywords: DEX; dexamethasone; ERK; extracellular signal-regulated kinases 1 and 2; eIF4E; eukaryotic initiation factor E; 4E-BP1; eIF4E-binding protein 1; FoxO; Forkhead box O Family of Transcription Factors; IGF-I; Insulin Growth Factor I; MTOR; mechanistic target
Inhibition of mTOR down-regulates scavenger receptor, class B, type I (SR-BI) expression, reduces endothelial cell migration and impairs nitric oxide production
Keywords: ABCG1; ATP binding cassette transporter G1; BP-C; Bodipy-cholesterol; BP-CE; Bodipy-cholesteryl oleate; CETP; cholesteryl ester transfer protein; DAF-2 DA; 4,5-diaminofluorescein diacetate; DiI; 1,1â²-dioctadecyl-3,3,3â²,3â²-tetramethylindocarbocyanine
Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells
Keywords: CRC; colorectal cancer; CPT; camptothecin; DSBs; double-strand breaks; DDR; DNA damage response; γ-H2AX; phosphorylated histone H2AX; ATM; ataxia telangiectasia mutated; Chk2; check-point kinase; AMPK; AMP-activated protein kinase; TSC2; tuberous scleros
Fisetin regulates obesity by targeting mTORC1 signaling
Keywords: mTORC1; mammalian target of rapamycin complex 1; S6K1; 70-kDa ribosomal protein S6 kinase 1; TSC2; tuberous sclerosis protein 2; HFD; high-fat diet; PPAR-γ; peroxisome proliferator-activated receptor γ; SREBP-1; sterol regulatory element-binding protein
Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence
Keywords: OIS; oncogene-induced senescence; MEF; mouse embryonic fibroblast; ERK; extracellular signal-regulated kinase; MEK; mitogen-activated protein kinase kinase; PI3K; phosphatidylinositol 3-kinase; pRb; retinoblastoma tumor suppressor protein; SA-β-Gal; sene
Detection of maternal transmission of a splicing mutation in the TSC2 gene following prenatal diagnosis of fetal cardiac rhabdomyomas mimicking congenital cystic adenomatoid malformation of the lung and cerebral tubers and awareness of a family history of
Keywords: cystic adenomatoid malformation of the lung; maternal epilepsy; MRI; prenatal diagnosis; TSC2; tuberous sclerosis complex
Impaired lipid accumulation in the liver of Tsc2-heterozygous mice during liver regeneration
Keywords: TSC; tuberous sclerosis; mTOR; mammalian target of rapamycin; GAP; GTPase-activating protein; MAPK; mitogen-activated protein kinase; p90 RSK; p90 ribosomal S6 kinase; ERK; extracellular signal-regulated kinase; P70S6K; p70 ribosomal S6 kinase; AMPK; 5â²
Functional inactivation of Rb sensitizes cancer cells to TSC2 inactivation induced cell death
Keywords: Rb pathway; Cyclin D1; p16ink4a; E1a; Pten; TSC2
XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons
Keywords: X-linked intellectual disability; Cullin 4B; TSC2; Cyclin E; mTOR; Neocortical neurons
Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex
Keywords: TSC, tuberous sclerosis complex; ASD, autism spectrum disorder; mTORC1, mammalian target of rapamycin complex 1Purkinje cell; Tuberous sclerosis; Rapamycin; Mouse; Tsc2; Autism; Social; Repetitive behavior
β-Arrestin signal complex plays a critical role in adipose differentiation
Keywords: GHSR1a; growth hormone secretagogue receptor type 1a; PPARγ; peroxisome proliferator-activated receptor; C/EBPα; CCAAT/enhancer-binding protein α; C/EBPβ; CCAAT/enhancer-binding protein β; C/EBPδ; CCAAT/enhancer-binding protein δ; PI3K; phosphatidy
Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin
Keywords: ADHD; attention deficit hyperactivity disorder; ASD; autism spectrum disorders; GAP; GTPase-activating protein; TSC; tuberous sclerosis complex; TSC2-DN; TSC2-dominant/negative; Tuberous sclerosis complex; Autism; TSC2; GAP domain; mTORC1; Social interact
Avian influenza A virus H5N1 causes autophagy-mediated cell death through suppression of mTOR signaling
Keywords: Avian influenza; H5N1; Autophagy; mTOR; TSC2; PTEN
Two different types of infantile renal cell carcinomas associated with tuberous sclerosis
Keywords: Tuberous sclerosis; Renal cell carcinoma; TSC2
Lithium induces c-Ret expression in mouse inner medullary collecting duct cells
Keywords: Li+; lithium; mIMCD; murine inner medullary collecting duct; GSK-3β; glycogen synthase kinase 3β; BIO; 6-bromoindirubin-3â²-oxime; TCF/LEF; T cell factor/lymphoid enhancer factor; mTOR; mammalian target of rapamycin; Ret; REarranged during Transfection
cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity
Keywords: cAMP; mTORC1; mTORC2; TSC2; PKA;
Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass
Keywords: 4E-BP1; 4E binding protein 1; 5â²UTR; 5â² untranslated region; AICAR; 5-aminoimidazole-4-carboxamide riboside; AMP; adenosine monophosphate; AMPK; 5â²-AMP-activated protein kinase; AMPK α1â/â; AMPK α1 subunit knockout; AMPKα1â/âα2â/â; A
Biomarkers and Patient Selection for PI3K/Akt/mTOR Targeted Therapies: Current Status and Future Directions
Keywords: HER2; PI3KCA; PTEN; TSC1; TSC2
Adiponectin Modulates C-Jun N-Terminal Kinase and Mammalian Target of Rapamycin and Inhibits Hepatocellular Carcinoma
Keywords: Hepatocellular Carcinoma; Adiponectin; TSC2; mTOR; AMPK; adenosine monophosphateâactivated protein kinase; BMI; body mass index; HCC; hepatocellular carcinoma; JNK; c-Jun-N-terminal kinase; mTOR; mammalian target of rapamycin; TMA; tissue microarray; TS