cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity

► cAMP inhibits mTORC1 and mTORC2. ► cAMP causes the dissociation of mTORC1 and 2. ► cAMP inhibits mTORC1 independently of TSC2, Rheb, Rag GTPases, PKB, MAPK and AMPK. ► cAMP inhibits TORC1 via a PKA-dependent mechanism.