کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8455576 1548028 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular simulations predict novel collagen conformations during cross-link loading
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Molecular simulations predict novel collagen conformations during cross-link loading
چکیده انگلیسی
Collagen cross-linking mechanically strengthens tissues during development and aging, but there is limited data describing how force transmitted across cross-links affects molecular conformation. We used Steered Molecular Dynamics (SMD) to model perpendicular force through a side chain. Results predicted that collagen peptides have negligible bending resistance and that mechanical force causes helix disruption below covalent bond failure strength, suggesting alternative molecular conformations precede cross-link rupture and macroscopic damage during mechanical loading.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Matrix Biology - Volume 30, Issues 5–6, June 2011, Pages 356-360
نویسندگان
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