Benzo[a]pyrene-induced cell cycle progression occurs via ERK-induced Chk1 pathway activation in human lung cancer cells

- B[a]P phosphorylated phospho-Chk1 via p-ERK.
- P-ERK promoted to p-c-Myc bind to E-box response element.
- Phospho-Chk1 activated p-p53 and induced S-phase accumulation.