دانلود مقالات ISI درباره Chk1 + ترجمه فارسی

علل شیوه زندگی ناباروری مردانه

Lifestyle causes of male infertility

Keywords: AAS; anabolic-androgenic steroids; APA; advanced paternal age; ASIH; anabolic steroid-induced hypogonadism; ART; assisted reproductive technology; BMI; body mass index; Chk1; checkpoint kinase 1; ECS; endogenous cannabinoid system; GnIH; gonadotropin-in

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

سیلیکا - عنصر ژئوشیمیایی ردیابی با پدیده نفوذپذیری در حال ظهور است

Silica - A trace geogenic element with emerging nephrotoxic potential

Keywords: Apaf-1; Apoptotic protease-activating factor-1; A498; Renal proximal tubular carcinoma; BCA; Bicinchoninic acid; Bax; Bcl-2 associated X protein; Bcl-2; B-cell lymphoma 2; BSA; Bovine Serum Albumin; Cdc25; Cell-division control protein 25(Dual-Specificity

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2018 سفارش ترجمه

ترکیب شیمیایی و درمان مولکولی هدفمند

Integrating chemoradiation and molecularly targeted therapy

Keywords: SBRT; Stereotactic body radiation therapy; 5-FU; 5-fluorouracil; FdUMP; Fluoro-deoxyuridine-monophosphate; FdUTP; Fluoro-deoxyuridine-triphosphate; FUTP; Fluorouridine triphosphate; CHK1; Checkpoint kinase 1; PARP; Poly(ADP-ribose) polymerase; EGFR; Epide

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

پس زدن به عنوان نقطه پایانی بیولوژیک پس از هدف گذاری فارماکولوژیک گیرنده های تیروزین کیناز در سرطان

Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer

Keywords: ATIR; anti-tumor immune response; ATM; ataxia telangiectasia mutated; CDK; cyclin-dependent kinase; CGH; comparative genomic hybridization; CHK1; checkpoint kinase 1; CHK2; checkpoint kinase 2; DDAs; DNA-damaging agents; DDR; DNA damage response; DSBs; do

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

کشف کلاس 1،7 دیازاکاربازول مهارکننده های پروتئین کیناز 1

Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1

Keywords: RUXBJTDGOHITBG-UHFFFAOYSA-N; AVGXCPYDUVBUKP-UHFFFAOYSA-N; PVRJSOWSQUNARV-UHFFFAOYSA-N; VRCZLPVQUNNREW-UHFFFAOYSA-N; ChK1; Checkpoint; Structure-based design; Diazacarbazole; GNE-783;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

بررسی پروتئین کیناز 1 نشان دهنده حساسیت به درمان با مهار بازرسی کیناز 1 در سلول های ریه سلول های غیر سلولی است

Checkpoint kinase 1 protein expression indicates sensitization to therapy by checkpoint kinase 1 inhibition in non–small cell lung cancer

Keywords: CHK1; NSCLC cell lines; Combination therapies; AZD7762; Chemosensitivity; Radiosensitivity

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

استرس تکراری و سرطان: دو تا تانگو طول می کشد

Replication stress and cancer: It takes two to tango

Keywords: Replication Stress; ATR; CHK1; Cancer;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

نقش دوگانهیون در طی تکثیر و تفریف تروفوبلاست

The dual roles of geminin during trophoblast proliferation and differentiation

Keywords: Geminin; Trophoblast stem cells; Trophoblast giant cells; Differentiation; Trophectoderm; Endoreplication; Endocycles; Chk1; Cdkn1a/p21/Cip1; Cdkn1c/p57/Kip2;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

KRAS-Mutant non-small cell lung cancer: From biology to therapy

Keywords: BATTLE; Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination; BET; bromodomains and extra-terminal domain; CDK; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CI; confidence interval; CUSTOM; Molecular Profiling and Targete

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Melanoma antigen-D2 controls cell cycle progression and modulates the DNA damage response

Keywords: APC/C; anaphase-promoting complex or cyclosome; ATM; ataxia-telangiectasia mutated protein; ATR; ataxia-telangiectasia- and rad3-related protein; CDC20; cell division cycle protein 20; CDK; cyclin-dependent kinase; CHK1; checkpoint kinase 1; CHK2; checkpo

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

CCRK is a novel signalling hub exploitable in cancer immunotherapy

Keywords: 9G8; serine and arginine rich splicing factor 7; AKT; AKT serine/threonine kinase; AR; androgen receptor; ARE; androgen response element; ARG1; arginase 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3-related protein; BMDC; mous

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

DNA damage and repair proteins in cellular response to sulfur mustard in Iranian veterans more than two decades after exposure

Keywords: CHK1; checkpoint kinase 1 human protein; CHK2; checkpoint kinase 2 human protein; COPD; chronic obstructive pulmonary disease; DSB; double-strand breaks; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSH; glutathione; γH2AX; phosphorylated H2AX; MRN;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2018 سفارش ترجمه

Harmines inhibit cancer cell growth through coordinated activation of apoptosis and inhibition of autophagy

Keywords: Harmine; Anticancer effect; DNA damage response; Autophagy; Apoptosis; ATR; ATM and Rad3-related; CPT; camptothecin; cck-8; cell count kit-8; Chk1; checkpoint kinase 1; DOX; doxorubicin; PARP; poly (ADP-ribose) polymerase; PI; propidium iodide; UPLC-Q-TOF

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2018 سفارش ترجمه

DNA repair mechanisms in response to genotoxicity of warfare agent sulfur mustard

Keywords: ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3 related; BER; base excision repair; Cdc25; cell division cycle 25; CDKs; cyclin-dependent kinases; CEES; 2-chloroethyl ethyl sulphide; ChK1; checkpoint kinase 1; Chk2; checkpoint kina

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells

Keywords: ABTS; 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); CAT; catalase; Chk1; checkpoint kinase 1; H2DCFDA; 2′,7′-dichlorodihydrofluorescein diacetate; HMEC-1; human microvascular endothelial cells; HMTs; histone methyltransferases; TAC; total

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Development and validation of a sensitive LC MS/MS method for the measurement of the checkpoint kinase 1 inhibitor prexasertib and its application in a cerebral microdialysis study

Keywords: Prexasertib; Chk1; LC-MS/MS; Liquid-liquid extraction; Microdialysis; Ringer's solution;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Camptosorus sibiricus rupr aqueous extract prevents lung tumorigenesis via dual effects against ROS and DNA damage

Keywords: CSR; Camptosorus sibiricus Rupr; B[a]P; benzo(a)pyrene; ROS; reactive oxygen species; UPLC-DAD-QTOF; Ultra performance liquid chromatography-Diode array detector-QTOF; HPLC DMEM; High Performance Liquid Chromatography Dulbecco's modified Eagle's medium; M

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

Keywords: Autophagy; Combination therapy; Erlotinib; Vps34; High-content screening; AKT; Protein kinase B; ATG7; Autophagy-related protein 7; BafA1; Bafilomycin A1; Chk1; Checkpoint kinase 1; CQ; Chloroquine; FGFR; Fibroblast growth factor receptor; GFP; Green fluo

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Cross-species comparison of the gut: Differential gene expression sheds light on biological differences in closely related tenebrionids

Keywords: Tenebrionid gut; Gut transcriptome; Tribolium castaneum; Tenebrio molitor; BP; Biological Process; CC; Cellular Component; CHK1; checkpoint kinase 1; HEX3; hexamerin 3; INDY; I'm not dead yet; GO; gene ontology; MF; molecular function; PPK28; pickpocket

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

A randomized, phase 2 evaluation of the CHK1 inhibitor, LY2603618, administered in combination with pemetrexed and cisplatin in patients with advanced nonsquamous non‐small cell lung cancer

Keywords: CHK1; selective inhibitor of checkpoint kinase 1; LY + Pem + Cis; LY2603618 + pemetrexed + cisplatin; Pem + Cis; pemetrexed + cisplatin; Checkpoint kinase 1; Cisplatin; Pemetrexed; LY2603618; Non-small cell lung cancer;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Research paperPotent induction of apoptosis by givinostat in BCR-ABL1-positive and BCR-ABL1-negative precursor B-cell acute lymphoblastic leukemia cell lines

Keywords: Acute lymphoblastic leukemia; Givinostat; Apoptosis; CHK1; FANCD2;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Radiobiology of head and neck cancerG2-checkpoint targeting and radiosensitization of HPV/p16-positive HNSCC cells through the inhibition of Chk1 and Wee1

Keywords: HPV; HNSCC; Chk1; Wee1; G2-arrest; Radiosensitization;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

APCCdh1 controls cell cycle entry during liver regeneration

Keywords: APC/C; anaphase-promoting complex/cyclosome; SCF; Skp1/CUL1/F-box protein; PHx; partial hepatectomy; QRT-PCR; quantitative reverse transcription-PCR; Chk1; checkpoint kinase 1; Cdh1; Replication; Liver regeneration;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular basis for the regulation of the circadian clock kinases CK1δ and CK1ε

Keywords: ATP; adenosine triphosphate; CK1; casein kinase 1; CK2; casein kinase 2; CTD; C-terminal domain; TTFL; transcriptional and translational feedback loop; GSK-3β; glycogen synthase kinase 3β; MEFs; mouse embryonic fibroblast cells; ConA; concanavalin A; LP

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Research paperRandomized phase II trial of cytosine arabinoside with and without the CHK1 inhibitor MK-8776 in relapsed and refractory acute myeloid leukemia

Keywords: Leukemia; AML; Chk1; Cytarabine; MK-8776;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

E2F6 protein levels modulate drug induced apoptosis in cardiomyocytes

Keywords: α-mhc; α-myosin heavy chain; β2-AR; beta-2-adrenergic receptor; Bax; Bcl2 associated protein X; Bcl2; B-cell lymphoma 2; Blm2; bloom syndrome 2 homolog; Bnip3; Bcl2 interacting protein 3; Chk1; checkpoint kinase 1; c-src; proto-oncogene tyrosine protei

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Reverting p53 activation after recovery of cellular stress to resume with cell cycle progression

Keywords: AMPK; AMP - activate kinase alpha 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; CHK2; checkpoint kinase 2; CHK1; checkpoint kinase 1; CDK; cyclin-dependent kinase; CDKN2A; cyclin dependent kinase inhibitor 2A;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticlemiR-875-5p counteracts epithelial-to-mesenchymal transition and enhances radiation response in prostate cancer through repression of the EGFR-ZEB1 axis

Keywords: microRNAs; Prostate cancer; Radiosensitivity; EMT; EGFR; CHK1; Checkpoint kinase 1; EGFR; Epidermal growth factor receptor; EMT; Epithelial-to-mesenchymal transition; HR; Homologous recombination; LIN7C; Lin-7 homolog C; miRNA; microRNA; NHEJ; Non homolog

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells

Keywords: CDDP; cisplatin; Chk1; checkpoint kinase 1; Chk2; checkpoint kinase 2; γ-H2AX; phosphorylated histone H2AX at Ser 139; LA-12; (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV); PARP; poly (ADP-ribose) polymerase; PBS; phosphate-buffered

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleMutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors

Keywords: Polo-like kinase 1; Head neck squamous cell carcinoma; WEE1; CHK1; AJUBA; AUC; area under the curve; BrdU; bromodeoxyuridine; CCC; concordance correlation coefficient; CHK1/2; checkpoint kinases 1 and 2; FDR; false-discovery rate; HNSCC; head and neck squ

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

DNA damage response inhibitors: Mechanisms and potential applications in cancer therapy

Keywords: ATM; ATR; CHK1; WEE1; DNA damage response; Targeted therapy; Combination strategies;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Xanthatin triggers Chk1-mediated DNA damage response and destabilizes Cdc25C via lysosomal degradation in lung cancer cells

Keywords: Xanthatin; DNA damage response; Chk1; Cdc25C; Lysosomal proteolysis;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

CHK1 and replicative stress in T-cell leukemia: Can an irreverent tumor suppressor end up playing the oncogene?

Keywords: CHK1; Replicative stress; ATR; ATM; T-ALL; T-cell acute lymphoblastic leukemia; Targeted therapies;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Mdc1 modulates the interaction between TopBP1 and the MRN complex during DNA damage checkpoint responses

Keywords: Mdc1; TopBP1; MRN complex; Nbs1; DNA damage checkpoint; DSB; double-stranded DNA break; Mdc1; mediator of DNA damage checkpoint protein 1; Chk1; checkpoint kinase 1; ATM; ataxia-telangiectasia mutated; ATR; ATM and Rad3-related; IR; ionizing radiation; si

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

ReviewEnhancement of arabinocytosine (AraC) toxicity to AML cells by a differentiation agent combination

Keywords: Vitamin D analog; AraC; Plant antioxidant; Acute myeloid leukemia (AML); Apoptosis; VDR; Chk1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Dual roles of ERK1/2 in cellular senescence induced by excess thymidine in HeLa cells

Keywords: Cellular senescence; ERK1/2; Chk1; Excess thymidine; DNA damage response

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells

Keywords: API5; apoptosis inhibitor 5; ARF1; ADP ribosylation factor 3; BCA; bicinchoninic acid; BBC3/PUMA; BCL2 binding component 3; BIRC5; baculoviral IAP (inhibitor of apoptosis) repeat containing 5; CDC25A; cell division cycle 25A; CDK4; cyclin-dependent kinase

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Chk1 inhibitor synergizes quinacrine mediated apoptosis in breast cancer cells by compromising the base excision repair cascade

Keywords: 9-Aminoacridine; Base-excision repair; CHK1; Breast cancer; Quinacrine

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Chk1 phosphorylated at serine345 is a predictor of early local recurrence and radio-resistance in breast cancer

Keywords: Breast cancer; Local recurrence; Radiotherapy; Resistance; p53; Chk1; ATR inhibitor; Chk1 inhibitor;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Original ArticleInhibition of ATR-dependent feedback activation of Chk1 sensitises cancer cells to Chk1 inhibitor monotherapy

Keywords: Chk1; ATR; ATM; DNA-PK; Kinase inhibitor; Replication stress;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

Keywords: ATR; CHK1; synthetic lethality; cancer; DNA damage; replication stress

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition

Keywords: Chk1; mTOR; DNA-PKcs; V158411; Double strand break repair;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Dietary flavonoid derivatives enhance chemotherapeutic effect by inhibiting the DNA damage response pathway

Keywords: Dietary flavonoids; Cisplatin; Chemotherapy sensitizer; DNA damage response; Chk1;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2016 سفارش ترجمه

Radiation activated CHK1/MEPE pathway may contribute to microgravity-induced bone density loss

Keywords: Linear energy transfer; (LET); Ionizing radiation; (IR); Matrix extracellular phosphoglycoprotein; (MEPE); Acidic serine- and aspartate-rich motif; (ASARM); Amino acids; (aa); Small integrinbinding ligand, N-linked glycoproteins; (SIBLINGs); Ionizing radi

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts

Keywords: ATR; Chk1; DNA damage response; REV1; TLS;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation

Keywords: Tumorigenesis; UNC45A; Hsp90; Chaperone; ChK1; Centrosome;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticleHepatitis B virus induces RNR-R2 expression via DNA damage response activation

Keywords: HBV; hepatitis B virus; dNTPs; deoxyribonucleotide triphosphates; Chk1; checkpoint kinase 1; RNR; ribonucleotide reductase; DDR; DNA damage response; PHH; primary human hepatocytes; SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; qRT-

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

ATR signaling cooperates with ATM in the mechanism of low dose hypersensitivity induced by carbon ion beam

Keywords: IR; ionizing radiation; LET; linear energy transfer; HRS; hyper-radiosensitivity; IRR; induced radioresistance; DSB; DNA double strand break; ATM; ataxia telangiectasia mutated homolog; ATR; ataxia telangiectasia and Rad3 related; DNA-PKcs; DNA-dependent

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Myc induced replicative stress response: How to cope with it and exploit it

Keywords: Myc; Replicative stress; DNA replication; ATR; Chk1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Benzo[a]pyrene-induced cell cycle progression occurs via ERK-induced Chk1 pathway activation in human lung cancer cells

Keywords: S phase accumulation; Benzo[a]pyrene; ERK; Chk1; P-p53;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه