Myc induced replicative stress response: How to cope with it and exploit it
Keywords: Myc; Replicative stress; DNA replication; ATR; Chk1;
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The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells
Keywords: Proliferating Cell Nuclear Antigen (PCNA); MYC; MYCN; Replication stress; Neuroblastoma; DNA damage response; Chk1
Chk1 and Wee1 control genotoxic-stress induced G2-M arrest in melanoma cells
Keywords: Tumour biology; Cell signalling; Cell cycle; Chk1; Wee1;
hHR23A is required to control the basal turnover of Chk1
Keywords: Chk1; hHR23A; Cell cycle
Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury
Keywords: ApG; adenine-guanine; ATM; Ataxia telangiectasia mutated; ATR; ATM and Rad3 related kinase; Bax; Bcl2-associated X protein; Bcl2; B-cell CLL/lymphoma 2; EdU; 5-ethynyl-2â²-deoxyuridine; CarboPt; carboplatin; CENP-F; centromere protein F; Chk1; checkpoint
Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme
Keywords: PDK1 inhibitors; Kinase inhibitors; Oxindole derivatives; Glioblastoma; GBM stem cells; Multi-target therapy; PI3K; phosphatidylinositol-3-kinase; PDK1; phosphoinositide-dependent kinase-1; GSK3; Glycogen synthase kinase 3; CHK1; Checkpoint kinase-1; Akt;
Chk1 is required for the metaphase–anaphase transition via regulating the expression and localization of Cdc20 and Mad2
Keywords: Chk1; Cdc20; Mad2; Spindle checkpoint; Metaphase–anaphase transition
The inhibition of PARP but not EGFR results in the radiosensitization of HPV/p16-positive HNSCC cell lines
Keywords: HPV; HNSCC; EGFR; PARP; Chk1; Radiosensitivity;
The identification of novel 5â²-amino gemcitabine analogs as potent RRM1 inhibitors
Keywords: Ribonucleotide reductase; Gemcitabine; CHK1; Deoxyribonucleotides; Oncology;
Targeting CHK1 inhibits cell proliferation in FLT3-ITD positive acute myeloid leukemia
Keywords: Acute myeloid leukemia; FLT3-ITD; CHK1; Cell cycle; Cell signaling; Proliferation
Chk1 as a new therapeutic target in triple-negative breast cancer
Keywords: Cell growth; Chk1; Mitotic catastrophe; Triple-negative breast cancer;
Opportunities for translation: Targeting DNA repair pathways in pancreatic cancer
Keywords: ATR; ATM-Rad3-related; BER; base excision repair; Chk1; checkpoint kinase 1; DDR; DNA damage response and repair; DNA-PKcs; DNA-PK catalytic subunit; DOT1L; DOT1-like; DSB; double strand break; FOLFIRINOX; folinic acid, 5-FU, irinotecan, oxaliplatin; 5-FU
CHEK again: Revisiting the development of CHK1 inhibitors for cancer therapy
Keywords: CHK1; Checkpoint kinase 1; DNA replication; WEE1; DNA damage responseATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3 related; CHK1, Checkpoint Kinase 1; CHK2, Checkpoint Kinase 2; CDKs, Cyclin-dependent kinases; DDK, DBF4/DRF1-dependent CDC7 kinase;
Benzo[a]pyrene-induced cell cycle arrest in HepG2 cells is associated with delayed induction of mitotic instability
Keywords: Benzo[a]pyrene; Chk1; S-phase arrest; Mitotic abnormalities; Carcinogenesis;
Inhibition of autophagy enhances DNA damage-induced apoptosis by disrupting CHK1-dependent S phase arrest
Keywords: DNA alkylating agent; DNA damage; S phase arrest; CHK1; Apoptosis; Autophagy;
A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA)
Keywords: APC; allophycocyanin; ATR; ataxia telangiectasia mutated and rad3-related; BCA; bicinchoninic acid; Chk1; checkpoint kinase 1; CSK buffer; cytoskeleton buffer; DBU; 1,8-diazabicyclo[5.4.0]undec-7-ene; DCM; dichloromethane; DIPEA; N,N-diisopropylethylamine
Applications of NMR screening techniques to the pharmaceutical target Checkpoint kinase 1
Keywords: AEBSF; 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride; Chk1; Checkpoint kinase 1; DIRECTION; Difference of Inversion REcovery rate with and without Target IrradiatiON; DSBs; double strand breaks; HEPES; 4-(2-HydroxyEthyl)-1-PiperazineEthaneSulfoni
Potency switch between CHK1 and MK2: Discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors
Keywords: Potency switch; CHK1; MK2; Kinase; Inhibitor;
HPV-positive HNSCC cell lines but not primary human fibroblasts are radiosensitized by the inhibition of Chk1
Keywords: HPV; p16; HNSCC; Chk1; G2-arrest; Radiosensitivity;
WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling
Keywords: ATR; Chk1; DNA damage checkpoint; TopBP1; WD40; WDR18;
Oxidative stress-induced cyclin D1 depletion and its role in cell cycle processing
Keywords: Oxidative stress; Cell cycle; Proteolysis; Translational repression; Chk1;
CHK1 cleavage in programmed cell death is intricately regulated by both caspase and non-caspase family proteases
Keywords: CHK1; DNA damage response; Programmed cell death; Caspase family proteases; Non-caspase family proteases
Implication of RPA32 phosphorylation in S-phase checkpoint signalling at replication forks stalled with aphidicolin in Xenopus egg extracts
Keywords: ATR; Replication stress; Chk1; Replication protein A;
DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism
Keywords: CHK1; DNA damage; cis-Autophosphorylation; ATR; Kinase
Ultrasound activates ataxia telangiectasia mutated- and rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway in human leukemia Jurkat cells
Keywords: Ultrasound; DNA damage; Chk1; ATR; Apoptosis
Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors
Keywords: Triazolones; CHK1; Checkpoint kinase 1; In vivo activity
Disruptive cell cycle regulation involving epigenetic downregulation of Cdkn2a (p16Ink4a) in early-stage liver tumor-promotion facilitating liver cell regeneration in rats
Keywords: BNF; β-naphthoflavone; Cdc2; cell division cycle 2; Cdc25c; cell division cycle 25 homolog C (S. pombe); Cdk; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CKI; cyclin-dependent kinase inhibitor; DEN; N-diethylnitrosamine; FB; fenbendazole; γH2AX;
Celecoxib Enhances the Radiosensitizing Effect of 7-Hydroxystaurosporine (UCN-01) in Human Lung Cancer Cell Lines
Keywords: Celecoxib; Chk1; COX-2; Radiosensitization; UCN-01;
BRCA1-dependent Chk1 phosphorylation triggers partial chromatin disassociation of phosphorylated Chk1 and facilitates S-phase cell cycle arrest
Keywords: ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia mutated and RAD3-related kinase; EGFP; enhanced green fluorescence protein; HU; hydroxyurea; IR; ionizing radiation; PI; propidium idodide; PI3K; phosphoinositide 3-kinases; RT-PCR; reverse tr
Berberine, a genotoxic alkaloid, induces ATM-Chk1 mediated G2 arrest in prostate cancer cells
Keywords: Berberine; G2/M arrest; ATM; Chk1; p53
Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance
Keywords: Melanoma; Methotrexate; E2F1; Chk1; DNA damage
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography
Keywords: 53BP1; Tp53 binding protein 1; 9-1-1; RAD9-RAD1-HUS1 checkpoint clamp complex; a.a.; amino acid; ACF1; ATP-utilizing chromatin assembly and remodeling factor 1; ALC1; amplified in liver cancer 1; APLF/PALF; aprataxin and PNKP-like factor; Aprataxi
Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1
Keywords: Kinase; CHK1; Pyrazolo[1,5-a]pyrimidine; Template;
Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 2
Keywords: Kinase; CHK1; Pyrazolo[1,5-a]pyrimidine; CDK; Cell cycle; Inhibitors;
Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy
Keywords: Chk1; Chk1inhibitor; AZD7762; Radiosensitivity; DNA damage checkpointDSB, double-stranded DNA break; Chk1, checkpoint kinase 1; ATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3-related; IR, ionizing radiation; MBT, metastatic brain tumor; shRNA, smal
Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugs
Keywords: ATR; Chk1; Cancer therapy
Molecular and Cellular PharmacologyInvolvement of Chk1-Cdc25A-cyclin A/CDk2 pathway in simvastatin induced S-phase cell cycle arrest and apoptosis in multiple myeloma cells
Keywords: Simvastatin; S phase arrest; Chk1; Cyclin dependent kinase 2; Cdc25A;
Glucose deprivation is associated with Chk1 degradation through the ubiquitin-proteasome pathway and effective checkpoint response to replication blocks
Keywords: Chk1; Glucose deprivation; Protein stability; Ubiquitin-proteasome pathway; Genomic instability;
Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition
Keywords: PARP inhibitor; Methyl methanesulfonate; NBS1; SMC1; Cell cycle; Chk1; Chk2
Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases
Keywords: CHK1; Kinase inhibitors; Imidazopyrazines;
Menin stimulates homology-directed DNA repair
Keywords: Menin; MEN1; Homologous recombination; DNA damage; Chk1
Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors—Hit to lead exploration
Keywords: Triazolones; CHK1; Checkpoint Kinase inhibitors
HTLV-1 Tax: Linking transformation, DNA damage and apoptotic T-cell death
Keywords: AP-1; activator protein 1; APC; anaphase promoting complex; ATL; adult T-cell leukemia; ATM kinase; ataxia telangiectasia mutated kinase; BES; base excision repair; Chk1; checkpoint kinase 1; Chk2; checkpoint kinase 2; CREB; cyclic AMP response element-bi
The ATR barrier to replication-born DNA damage
Keywords: ATR; Chk1; Cancer; DNA damage response; Ageing
RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells
Keywords: HT-RNAi; ATR; CHK1; PRKAB1; Cisplatin; Ovarian cancer
The Effects of G2-Phase Enrichment and Checkpoint Abrogation on Low-Dose Hyper-Radiosensitivity
Keywords: Ionizing radiation; Low dose; Cell cycle; G2 checkpoint arrest; Chk1; Chk2;
Checkpoint kinase 1 modulates sensitivity to cisplatin after spindle checkpoint activation in SW620 cells
Keywords: Mis-segregation; Chk1; Mad3/BubR1; Genotoxic stress; Mitotic checkpoint;
Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells
Keywords: Thymidine kinase; Ganciclovir; Pancreatic cancer; Cell cycle; Chk1
Development of thioquinazolinones, allosteric Chk1 kinase inhibitors
Keywords: Chk1; Thioquinazolinone; Allosteric kinase inhibitor; X-ray crystal structure
DNA damage responses in skin biology—Implications in tumor prevention and aging acceleration
Keywords: DNA damage; Senescence; Checkpoint; Chk1; Transcription